Lack of association between promoter polymorphisms of HLA-G gene and rheumatoid arthritis in Korean population
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Kim, S. K. | - |
dc.contributor.author | Chung, J. H. | - |
dc.contributor.author | Kim, D. H. | - |
dc.contributor.author | Yun, D. H. | - |
dc.contributor.author | Hong, S. J. | - |
dc.contributor.author | Lee, K. H. | - |
dc.date.accessioned | 2022-07-16T16:48:54Z | - |
dc.date.available | 2022-07-16T16:48:54Z | - |
dc.date.created | 2021-05-12 | - |
dc.date.issued | 2012-02 | - |
dc.identifier.issn | 0172-8172 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/hanyang/handle/2021.sw.hanyang/166351 | - |
dc.description.abstract | The aim of this study was to determine whether the HLA-G gene was associated with susceptibility to rheumatoid arthritis (RA). Major histocompatibility complex, class I, G (HLA-G) is involved in immunoregulatory processes and particularly in pathogenesis of inflammatory disorders. To investigate possible association between HLA-G and RA, 296 RA patients and 468 healthy controls were enrolled in this study. Two-promoter single-nucleotide polymorphisms (SNPs) (rs1736936, -1202T/C and rs2735022, -586C/T) in HLA-G gene were analyzed using polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP). For analysis of data, Helixtree software, SNPAnalyzer, SNPStats, and Haploview version 4.2 were used. Multiple logistic regression models (codominant, dominant, and recessive) were performed for odds ratio (OR), 95% confidence interval (CI), and P value. There were no significant differences in distributions of genotypes and haplotypes between RA patients and control subjects. In clinical features of RA, we found differences between C-reactive protein levels (a parts per thousand yen0.5 or < 0.5 mg/dL) and two-promoter SNPs. Rs1736936 was significant in codominant (P = 0.028, OR = 0.66, 95% CI = 0.45-0.96) and dominant (P = 0.046, OR = 0.58, 95% CI = 0.34-0.99) models. Also, rs2735022 was significant in codominant (P = 0.038, OR = 0.67, 95% CI = 0.46-0.98) and dominant (P = 0.03, OR = 0.55, 95% CI = 0.33-0.94) models. However, these significant associations disappear after Bonferroni correction. Our results suggest that HLA-G promoter polymorphisms may be not associated with the development of RA in Korean population. | - |
dc.language | 영어 | - |
dc.language.iso | en | - |
dc.publisher | SPRINGER HEIDELBERG | - |
dc.title | Lack of association between promoter polymorphisms of HLA-G gene and rheumatoid arthritis in Korean population | - |
dc.type | Article | - |
dc.contributor.affiliatedAuthor | Lee, K. H. | - |
dc.identifier.doi | 10.1007/s00296-010-1735-4 | - |
dc.identifier.scopusid | 2-s2.0-84857047557 | - |
dc.identifier.wosid | 000299507900041 | - |
dc.identifier.bibliographicCitation | RHEUMATOLOGY INTERNATIONAL, v.32, no.2, pp.509 - 512 | - |
dc.relation.isPartOf | RHEUMATOLOGY INTERNATIONAL | - |
dc.citation.title | RHEUMATOLOGY INTERNATIONAL | - |
dc.citation.volume | 32 | - |
dc.citation.number | 2 | - |
dc.citation.startPage | 509 | - |
dc.citation.endPage | 512 | - |
dc.type.rims | ART | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
dc.description.isOpenAccess | N | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Rheumatology | - |
dc.relation.journalWebOfScienceCategory | Rheumatology | - |
dc.subject.keywordPlus | C reactive protein | - |
dc.subject.keywordPlus | HLA G antigen | - |
dc.subject.keywordPlus | adult | - |
dc.subject.keywordPlus | allele | - |
dc.subject.keywordPlus | article | - |
dc.subject.keywordPlus | clinical feature | - |
dc.subject.keywordPlus | computer program | - |
dc.subject.keywordPlus | controlled study | - |
dc.subject.keywordPlus | disease predisposition | - |
dc.subject.keywordPlus | DNA polymorphism | - |
dc.subject.keywordPlus | female | - |
dc.subject.keywordPlus | gene linkage disequilibrium | - |
dc.subject.keywordPlus | genotype | - |
dc.subject.keywordPlus | haplotype | - |
dc.subject.keywordPlus | human | - |
dc.subject.keywordPlus | immunoregulation | - |
dc.subject.keywordPlus | Korea | - |
dc.subject.keywordPlus | major clinical study | - |
dc.subject.keywordPlus | male | - |
dc.subject.keywordPlus | pathogenesis | - |
dc.subject.keywordPlus | polymerase chain reaction | - |
dc.subject.keywordPlus | population research | - |
dc.subject.keywordPlus | priority journal | - |
dc.subject.keywordPlus | restriction fragment length polymorphism | - |
dc.subject.keywordPlus | rheumatoid arthritis | - |
dc.subject.keywordPlus | single nucleotide polymorphism | - |
dc.subject.keywordAuthor | Association study | - |
dc.subject.keywordAuthor | HLA-G | - |
dc.subject.keywordAuthor | Single-nucleotide polymorphism | - |
dc.subject.keywordAuthor | Rheumatoid arthritis | - |
dc.identifier.url | https://link.springer.com/article/10.1007/s00296-010-1735-4 | - |
Items in ScholarWorks are protected by copyright, with all rights reserved, unless otherwise indicated.
222, Wangsimni-ro, Seongdong-gu, Seoul, 04763, Korea+82-2-2220-1365
COPYRIGHT © 2021 HANYANG UNIVERSITY.
Certain data included herein are derived from the © Web of Science of Clarivate Analytics. All rights reserved.
You may not copy or re-distribute this material in whole or in part without the prior written consent of Clarivate Analytics.