Oxidative stress in the haematopoietic niche regulates the cellular immune response in Drosophila
DC Field | Value | Language |
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dc.contributor.author | Sinenko, Sergey A. | - |
dc.contributor.author | Shim, Jiwon | - |
dc.contributor.author | Banerjee, Utpal | - |
dc.date.accessioned | 2022-07-16T16:57:57Z | - |
dc.date.available | 2022-07-16T16:57:57Z | - |
dc.date.created | 2021-05-13 | - |
dc.date.issued | 2012-01 | - |
dc.identifier.issn | 1469-221X | - |
dc.identifier.uri | https://scholarworks.bwise.kr/hanyang/handle/2021.sw.hanyang/166444 | - |
dc.description.abstract | Oxidative stress induced by high levels of reactive oxygen species (ROS) is associated with the development of different pathological conditions, including cancers and autoimmune diseases. We analysed whether oxidatively challenged tissue can have systemic effects on the development of cellular immune responses using Drosophila as a model system. Indeed, the haematopoietic niche that normally maintains blood progenitors can sense oxidative stress and regulate the cellular immune response. Pathogen infection induces ROS in the niche cells, resulting in the secretion of an epidermal growth factor-like cytokine signal that leads to the differentiation of specialized cells involved in innate immune responses. | - |
dc.language | 영어 | - |
dc.language.iso | en | - |
dc.publisher | Nature Publishing Group | - |
dc.title | Oxidative stress in the haematopoietic niche regulates the cellular immune response in Drosophila | - |
dc.type | Article | - |
dc.contributor.affiliatedAuthor | Shim, Jiwon | - |
dc.identifier.doi | 10.1038/embor.2011.223 | - |
dc.identifier.scopusid | 2-s2.0-84655170119 | - |
dc.identifier.wosid | 000299166200018 | - |
dc.identifier.bibliographicCitation | EMBO Reports, v.13, no.1, pp.83 - 89 | - |
dc.relation.isPartOf | EMBO Reports | - |
dc.citation.title | EMBO Reports | - |
dc.citation.volume | 13 | - |
dc.citation.number | 1 | - |
dc.citation.startPage | 83 | - |
dc.citation.endPage | 89 | - |
dc.type.rims | ART | - |
dc.type.docType | 정기학술지(Article(Perspective Article포함)) | - |
dc.description.journalClass | 1 | - |
dc.description.isOpenAccess | Y | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Biochemistry & Molecular Biology | - |
dc.relation.journalResearchArea | Cell Biology | - |
dc.relation.journalWebOfScienceCategory | Biochemistry & Molecular Biology | - |
dc.relation.journalWebOfScienceCategory | Cell Biology | - |
dc.subject.keywordPlus | cytokine | - |
dc.subject.keywordPlus | epidermal growth factor | - |
dc.subject.keywordPlus | protein kinase B | - |
dc.subject.keywordPlus | reactive oxygen metabolite | - |
dc.subject.keywordPlus | transcription factor FOXO | - |
dc.subject.keywordAuthor | FoxO | - |
dc.subject.keywordAuthor | haematopoietic niche | - |
dc.subject.keywordAuthor | haemocyte | - |
dc.subject.keywordAuthor | ROS | - |
dc.subject.keywordAuthor | Spitz | - |
dc.identifier.url | https://www.embopress.org/doi/full/10.1038/embor.2011.223 | - |
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