Influences of the G2350A polymorphism in the ACE Gene on cardiac structure and function of ball game players
DC Field | Value | Language |
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dc.contributor.author | Jang, Yongwoo | - |
dc.contributor.author | Kim, Sung Min | - |
dc.date.accessioned | 2022-07-16T16:59:45Z | - |
dc.date.available | 2022-07-16T16:59:45Z | - |
dc.date.created | 2021-05-13 | - |
dc.date.issued | 2012-01 | - |
dc.identifier.issn | 1477-5751 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/hanyang/handle/2021.sw.hanyang/166469 | - |
dc.description.abstract | Background: Except for the I/D polymorphism in the angiotensin I-converting enzyme (ACE) gene, there were few reports about the relationship between other genetic polymorphisms in this gene and the changes in cardiac structure and function of athletes. Thus, we investigated whether the G2350A polymorphism in the ACE gene is associated with the changes in cardiac structure and function of ball game players. Total 85 healthy ball game players were recruited in this study, and they were composed of 35 controls and 50 ball game players, respectively. Cardiac structure and function were measured by 2-D echocardiography, and the G2350A polymorphism in the ACE gene analyzed by the SNaPshot method. Results: There were significant differences in left ventricular mass index (LVmassI) value among each sporting discipline studied. Especially in the athletes of basketball disciplines, indicated the highest LVmassI value than those of other sporting disciplines studied (p < 0.05). However, there were no significant association between any echocardiographic data and the G2350A polymorphism in the ACE gene in the both controls and ball game players. Conclusions: Our data suggests that the G2350A polymorphism in the ACE gene may not significantly contribute to the changes in cardiac structure and function of ball game players, although sporting disciplines of ball game players may influence the changes in LVmassI value of these athletes. Further studies using a larger sample size and other genetic markers in the ACE gene will be needed. | - |
dc.language | 영어 | - |
dc.language.iso | en | - |
dc.publisher | BioMed Central | - |
dc.title | Influences of the G2350A polymorphism in the ACE Gene on cardiac structure and function of ball game players | - |
dc.type | Article | - |
dc.contributor.affiliatedAuthor | Jang, Yongwoo | - |
dc.contributor.affiliatedAuthor | Kim, Sung Min | - |
dc.identifier.doi | 10.1186/1477-5751-11-6 | - |
dc.identifier.scopusid | 2-s2.0-84862828770 | - |
dc.identifier.bibliographicCitation | Journal of Negative Results in BioMedicine, v.11, no.1, pp.1 - 7 | - |
dc.relation.isPartOf | Journal of Negative Results in BioMedicine | - |
dc.citation.title | Journal of Negative Results in BioMedicine | - |
dc.citation.volume | 11 | - |
dc.citation.number | 1 | - |
dc.citation.startPage | 1 | - |
dc.citation.endPage | 7 | - |
dc.type.rims | ART | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
dc.description.isOpenAccess | Y | - |
dc.description.journalRegisteredClass | scopus | - |
dc.subject.keywordPlus | dipeptidyl carboxypeptidase | - |
dc.subject.keywordPlus | ACE protein, human | - |
dc.subject.keywordPlus | dipeptidyl carboxypeptidase | - |
dc.subject.keywordPlus | adult | - |
dc.subject.keywordPlus | anatomical concepts | - |
dc.subject.keywordPlus | article | - |
dc.subject.keywordPlus | athlete | - |
dc.subject.keywordPlus | controlled study | - |
dc.subject.keywordPlus | DNA polymorphism | - |
dc.subject.keywordPlus | echocardiography | - |
dc.subject.keywordPlus | genetic identification | - |
dc.subject.keywordPlus | heart function | - |
dc.subject.keywordPlus | heart left ventricle mass | - |
dc.subject.keywordPlus | human | - |
dc.subject.keywordPlus | human experiment | - |
dc.subject.keywordPlus | amino acid substitution | - |
dc.subject.keywordPlus | athlete | - |
dc.subject.keywordPlus | case control study | - |
dc.subject.keywordPlus | echography | - |
dc.subject.keywordPlus | electrocardiography | - |
dc.subject.keywordPlus | genetics | - |
dc.subject.keywordPlus | heart | - |
dc.subject.keywordPlus | heart left ventricle hypertrophy | - |
dc.subject.keywordPlus | histology | - |
dc.subject.keywordPlus | organ size | - |
dc.subject.keywordPlus | pathophysiology | - |
dc.subject.keywordPlus | single nucleotide polymorphism | - |
dc.subject.keywordPlus | sport | - |
dc.subject.keywordPlus | Amino Acid Substitution | - |
dc.subject.keywordPlus | Athletes | - |
dc.subject.keywordPlus | Case-Control Studies | - |
dc.subject.keywordPlus | Electrocardiography | - |
dc.subject.keywordPlus | Heart | - |
dc.subject.keywordPlus | Humans | - |
dc.subject.keywordPlus | Hypertrophy, Left Ventricular | - |
dc.subject.keywordPlus | Organ Size | - |
dc.subject.keywordPlus | Peptidyl-Dipeptidase A | - |
dc.subject.keywordPlus | Polymorphism, Single Nucleotide | - |
dc.subject.keywordPlus | Sports | - |
dc.subject.keywordPlus | Young Adult | - |
dc.subject.keywordAuthor | ACE | - |
dc.subject.keywordAuthor | Ball Game Players | - |
dc.subject.keywordAuthor | Echocardiography | - |
dc.identifier.url | https://jnrbm.biomedcentral.com/articles/10.1186/1477-5751-11-6 | - |
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