Molecular imaging of a cancer-targeting theragnostics probe using a nucleolin aptamer- and microRNA-221 molecular beacon-conjugated nanoparticle
DC Field | Value | Language |
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dc.contributor.author | Kim, Jin Kyeoung | - |
dc.contributor.author | Choi, Kyung-Ju | - |
dc.contributor.author | Lee, Minhyung | - |
dc.contributor.author | Jo, Mi-hee | - |
dc.contributor.author | Kim, Soonhag | - |
dc.date.accessioned | 2022-07-16T17:00:45Z | - |
dc.date.available | 2022-07-16T17:00:45Z | - |
dc.date.created | 2021-05-12 | - |
dc.date.issued | 2012-01 | - |
dc.identifier.issn | 0142-9612 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/hanyang/handle/2021.sw.hanyang/166479 | - |
dc.description.abstract | MicroRNAs (miRNA, miR) have been reported as cancer biomarkers that regulate tumor suppressor genes. Hence, simultaneous detecting and inhibiting of miRNA function will be useful as a cancer theragnostics probe to minimize side effects and invasiveness. In this study, we developed a cancer-targeting therangostics probe in a single system using an AS1411 aptamer - and miRNA-221 molecular beacon (miR-221 MB)-conjugated magnetic fluorescence (MF) nanoparticle (MFAS miR-221 MB) to simultaneously target to cancer tissue, image intracellularly expressed miRNA-221 and treat miRNA-221-involved carcinogenesis. AS1411 aptamer-conjugated MF (MFAS) nanoparticles displayed a great selectivity and delivery into various cancer cell lines. The miR-221 MB detached from the MFAS miR-221 MB in the cytoplasm of C6 cells clearly imaged miRNA-221 biogenesis and simultaneously resulted in antitumor therapeutic effects by inhibiting miRNA function, indicating a successful astrocytoma-targeting theragnostics. MFAS miRNA MB can be easily applied to other cancers by simply changing a targeted miRNA highly expressed in cancers. | - |
dc.language | 영어 | - |
dc.language.iso | en | - |
dc.publisher | ELSEVIER SCI LTD | - |
dc.title | Molecular imaging of a cancer-targeting theragnostics probe using a nucleolin aptamer- and microRNA-221 molecular beacon-conjugated nanoparticle | - |
dc.type | Article | - |
dc.contributor.affiliatedAuthor | Lee, Minhyung | - |
dc.identifier.doi | 10.1016/j.biomaterials.2011.09.023 | - |
dc.identifier.scopusid | 2-s2.0-82855175161 | - |
dc.identifier.wosid | 000297399700021 | - |
dc.identifier.bibliographicCitation | BIOMATERIALS, v.33, no.1, pp.207 - 217 | - |
dc.relation.isPartOf | BIOMATERIALS | - |
dc.citation.title | BIOMATERIALS | - |
dc.citation.volume | 33 | - |
dc.citation.number | 1 | - |
dc.citation.startPage | 207 | - |
dc.citation.endPage | 217 | - |
dc.type.rims | ART | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
dc.description.isOpenAccess | N | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Engineering | - |
dc.relation.journalResearchArea | Materials Science | - |
dc.relation.journalWebOfScienceCategory | Engineering, Biomedical | - |
dc.relation.journalWebOfScienceCategory | Materials Science, Biomaterials | - |
dc.subject.keywordPlus | MESSENGER-RNA EXPRESSION | - |
dc.subject.keywordPlus | IN-VIVO | - |
dc.subject.keywordPlus | QUANTUM DOTS | - |
dc.subject.keywordPlus | KAPPA-B | - |
dc.subject.keywordPlus | CELLS | - |
dc.subject.keywordPlus | BIOGENESIS | - |
dc.subject.keywordPlus | DELIVERY | - |
dc.subject.keywordPlus | MIRNAS | - |
dc.subject.keywordPlus | SYSTEM | - |
dc.subject.keywordPlus | GENE | - |
dc.subject.keywordAuthor | Aptamer | - |
dc.subject.keywordAuthor | microRNA-221 | - |
dc.subject.keywordAuthor | Theragnostics | - |
dc.subject.keywordAuthor | Molecular beacon | - |
dc.subject.keywordAuthor | Multimodal nanoparticles | - |
dc.subject.keywordAuthor | Cancer targeting | - |
dc.identifier.url | https://www.sciencedirect.com/science/article/pii/S0142961211010647?via%3Dihub | - |
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