Surface modification of pancreatic islets using heparin-DOPA conjugate and anti-CD154 mAb for the prolonged survival of intrahepatic transplanted islets in a xenograft model
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Jung, Yoon Suk | - |
dc.contributor.author | Jeong, Jee-Heon | - |
dc.contributor.author | Yook, Simmyung | - |
dc.contributor.author | Im, Bok-Hyeon | - |
dc.contributor.author | Seo, Jinwon | - |
dc.contributor.author | Hong, Sung Woo | - |
dc.contributor.author | Park, Jun-Beom | - |
dc.contributor.author | Yan, Victor C. | - |
dc.contributor.author | Lee, Dong Yun | - |
dc.contributor.author | Byun, Youngro | - |
dc.date.accessioned | 2022-07-16T17:03:55Z | - |
dc.date.available | 2022-07-16T17:03:55Z | - |
dc.date.created | 2021-05-12 | - |
dc.date.issued | 2012-01 | - |
dc.identifier.issn | 0142-9612 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/hanyang/handle/2021.sw.hanyang/166502 | - |
dc.description.abstract | This study proposes a combination method of using 3,4-dihydorxy-t-phenylalanine (DOPA) conjugated heparin (heparin-DOPA) and a low dose of anti-CD154 monoclonal antibody (MR-1) treatment to improve the survival time of intrahepatic islet xenograft. To inhibit instant blood mediated inflammatory reactions, heparin-DOPA was directly grafted to the pancreatic islet surface. The surface coverage of heparin-DOPA, the viability and functionality of heparin-DOPA grafted islets were evaluated. In addition, the combined effect of grafted heparin-DOPA and a low dose of MR-1 (a T-cell targeting immunosuppressive drug) on the survival of islet was evaluated in a xenograft model. Both unmodified islets and heparin-DOPA grafted islets were completely rejected within 2 weeks after intraportal transplantation. However, when 0.1 mg/mouse of MR-1 was administered (at day 0, 2, 4, 6 of transplantation) to 11 mice that had heparin-DOPA grafted islets transplanted to, seven out of the recipients maintained normo-glycemia over 60 days. Therefore, we propose that a developed combinatory immunoprotection protocol of surface modification of pancreatic islets using heparin-DOPA with a low dose of MR-1 can be effective in prolonging the survival rate of transplanted islets in a xenograft model. | - |
dc.language | 영어 | - |
dc.language.iso | en | - |
dc.publisher | ELSEVIER SCI LTD | - |
dc.title | Surface modification of pancreatic islets using heparin-DOPA conjugate and anti-CD154 mAb for the prolonged survival of intrahepatic transplanted islets in a xenograft model | - |
dc.type | Article | - |
dc.contributor.affiliatedAuthor | Lee, Dong Yun | - |
dc.identifier.doi | 10.1016/j.biomaterials.2011.09.051 | - |
dc.identifier.scopusid | 2-s2.0-82855175136 | - |
dc.identifier.wosid | 000297399700029 | - |
dc.identifier.bibliographicCitation | BIOMATERIALS, v.33, no.1, pp.295 - 303 | - |
dc.relation.isPartOf | BIOMATERIALS | - |
dc.citation.title | BIOMATERIALS | - |
dc.citation.volume | 33 | - |
dc.citation.number | 1 | - |
dc.citation.startPage | 295 | - |
dc.citation.endPage | 303 | - |
dc.type.rims | ART | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
dc.description.isOpenAccess | N | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Engineering | - |
dc.relation.journalResearchArea | Materials Science | - |
dc.relation.journalWebOfScienceCategory | Engineering, Biomedical | - |
dc.relation.journalWebOfScienceCategory | Materials Science, Biomaterials | - |
dc.subject.keywordPlus | MEDIATED INFLAMMATORY REACTION | - |
dc.subject.keywordPlus | MONOCLONAL-ANTIBODY | - |
dc.subject.keywordPlus | EDMONTON PROTOCOL | - |
dc.subject.keywordPlus | TISSUE FACTOR | - |
dc.subject.keywordPlus | BLOOD | - |
dc.subject.keywordPlus | XENOTRANSPLANTATION | - |
dc.subject.keywordPlus | LANGERHANS | - |
dc.subject.keywordPlus | PEGYLATION | - |
dc.subject.keywordPlus | ALLOGRAFT | - |
dc.subject.keywordPlus | ADHESIVE | - |
dc.subject.keywordAuthor | Islet transplantation | - |
dc.subject.keywordAuthor | Surface modification | - |
dc.subject.keywordAuthor | Heparin | - |
dc.subject.keywordAuthor | DOPA | - |
dc.subject.keywordAuthor | Anti-CD154 monoclonal antibody | - |
dc.identifier.url | https://www.sciencedirect.com/science/article/pii/S0142961211011276?via%3Dihub | - |
Items in ScholarWorks are protected by copyright, with all rights reserved, unless otherwise indicated.
222, Wangsimni-ro, Seongdong-gu, Seoul, 04763, Korea+82-2-2220-1365
COPYRIGHT © 2021 HANYANG UNIVERSITY.
Certain data included herein are derived from the © Web of Science of Clarivate Analytics. All rights reserved.
You may not copy or re-distribute this material in whole or in part without the prior written consent of Clarivate Analytics.