Cyclic Changes in the Expression of p57(kip2) in Human Endometrium and its Regulation by Steroid Hormones in Endometrial Stromal Cells In Vitro
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Kim, Sung Tae | - |
dc.contributor.author | Lee, Sung Ki | - |
dc.contributor.author | Gye, Myung Chan | - |
dc.date.accessioned | 2022-07-16T17:04:33Z | - |
dc.date.available | 2022-07-16T17:04:33Z | - |
dc.date.created | 2021-05-12 | - |
dc.date.issued | 2012-01 | - |
dc.identifier.issn | 1933-7191 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/hanyang/handle/2021.sw.hanyang/166506 | - |
dc.description.abstract | We investigated the expressions of p57(kip2) and p27(kip) and its regulation by steroids in the normal and abnormal human endometrium. Endometrial p27(kip1) and p57(kip2) messenger RNA (mRNA) were markedly increased in the secretory phase. P57(kip2) protein was absent in proliferative phase but appeared in glandular epithelium together with early-to mid-secretory phase stromal cells. During the late secretory phase, strong p57(kip2) protein immunoreactivity was found in the stromal cells. In both endometrial hyperplasia and cancer, the expression of p57(kip2) protein was low. In cultured human endometrial stromal cells (ESCs), p27(kip1) mRNA levels were increased together with the decidual marker prolactin (prl), following treatment with 17 beta-estradiol (E2) and progesterone (P4). At 1 nmol/L, the glucocorticoid receptor (GR) agonist dexamethasone (DEX) induced prl, p57(kip2), and p27(kip1) mRNA in ESCs. Taken together, upregulation of p57(kip2) may play an important role in the decidual differentiation by P4 and growth inhibition of malignant cells in human endometrium. | - |
dc.language | 영어 | - |
dc.language.iso | en | - |
dc.publisher | SAGE PUBLICATIONS INC | - |
dc.title | Cyclic Changes in the Expression of p57(kip2) in Human Endometrium and its Regulation by Steroid Hormones in Endometrial Stromal Cells In Vitro | - |
dc.type | Article | - |
dc.contributor.affiliatedAuthor | Gye, Myung Chan | - |
dc.identifier.doi | 10.1177/1933719111414209 | - |
dc.identifier.scopusid | 2-s2.0-84855454875 | - |
dc.identifier.wosid | 000298855000011 | - |
dc.identifier.bibliographicCitation | REPRODUCTIVE SCIENCES, v.19, no.1, pp.92 - 101 | - |
dc.relation.isPartOf | REPRODUCTIVE SCIENCES | - |
dc.citation.title | REPRODUCTIVE SCIENCES | - |
dc.citation.volume | 19 | - |
dc.citation.number | 1 | - |
dc.citation.startPage | 92 | - |
dc.citation.endPage | 101 | - |
dc.type.rims | ART | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
dc.description.isOpenAccess | N | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Obstetrics & Gynecology | - |
dc.relation.journalResearchArea | Reproductive Biology | - |
dc.relation.journalWebOfScienceCategory | Obstetrics & Gynecology | - |
dc.relation.journalWebOfScienceCategory | Reproductive Biology | - |
dc.subject.keywordPlus | DEPENDENT KINASE INHIBITOR | - |
dc.subject.keywordPlus | PROGESTERONE-RECEPTOR EXPRESSION | - |
dc.subject.keywordPlus | CORTICOTROPIN-RELEASING HORMONE | - |
dc.subject.keywordPlus | GLUCOCORTICOID RECEPTOR | - |
dc.subject.keywordPlus | GENE-EXPRESSION | - |
dc.subject.keywordPlus | CDK INHIBITORS | - |
dc.subject.keywordPlus | MICE LACKING | - |
dc.subject.keywordPlus | PROLIFERATIVE ENDOMETRIUM | - |
dc.subject.keywordPlus | INVITRO DECIDUALIZATION | - |
dc.subject.keywordPlus | PROLACTIN PRODUCTION | - |
dc.subject.keywordAuthor | endometrium | - |
dc.subject.keywordAuthor | decidualization | - |
dc.subject.keywordAuthor | steroids | - |
dc.subject.keywordAuthor | p27(kip1) | - |
dc.subject.keywordAuthor | p57(kip2) | - |
dc.identifier.url | https://journals.sagepub.com/doi/10.1177/1933719111414209 | - |
Items in ScholarWorks are protected by copyright, with all rights reserved, unless otherwise indicated.
222, Wangsimni-ro, Seongdong-gu, Seoul, 04763, Korea+82-2-2220-1365
COPYRIGHT © 2021 HANYANG UNIVERSITY.
Certain data included herein are derived from the © Web of Science of Clarivate Analytics. All rights reserved.
You may not copy or re-distribute this material in whole or in part without the prior written consent of Clarivate Analytics.