Tianma modulates blood vessel tonicity
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Feng, Lin | - |
dc.contributor.author | Manavalan, Arulmani | - |
dc.contributor.author | Mishra, Manisha | - |
dc.contributor.author | Sze, Siu Kwan | - |
dc.contributor.author | Hu, Jiang-Miao | - |
dc.contributor.author | Heese, Klaus | - |
dc.date.accessioned | 2022-07-16T17:23:20Z | - |
dc.date.available | 2022-07-16T17:23:20Z | - |
dc.date.created | 2021-05-13 | - |
dc.date.issued | 2012 | - |
dc.identifier.issn | 1874-091X | - |
dc.identifier.uri | https://scholarworks.bwise.kr/hanyang/handle/2021.sw.hanyang/166604 | - |
dc.description.abstract | Tianma is a traditional Chinese medicine (TCM) often used for the treatment of hypertension and heart diseases. To elucidate the function of tianma at the molecular level, we investigated the effect of tianma on vascular functions and aortic protein metabolism. We found that long-term treatment with tianma (~2.5g/kg/day for three months) in one-year-old rats could enhance acetylcholine (ACh)-induced vasorelaxation in endothelium-intact thoracic aortic rings against both KCl (80 mM)-and phenylephrine (PE)-induced contraction. By using the iTRAQ (isobaric tag for relative and absolute quantification) technique, we confirmed from the functional data at the proteome level that tianma treatment down-regulated the expressions of contractile proteins (e.g. Acta2) and other related structural proteins (e.g. desmin), and up-regulated the expressions of extracellular matrix (ECM) glycoproteins (e.g. Fbln5) and anti-thrombotic proteins (e.g. Anxa2) in aortic tissue. By inductive reasoning, tianma could perform its vasodilatory effect not only by inhibiting vascular smooth muscle contraction, but also by enhancing blood vessel elasticity and stabilizing the arterial structure. Thus, tianma might become a novel therapeutic herbal medicine for cardiovascular diseases by regulating the aortic proteome metabolism. | - |
dc.language | 영어 | - |
dc.language.iso | en | - |
dc.publisher | Bentham Open | - |
dc.title | Tianma modulates blood vessel tonicity | - |
dc.type | Article | - |
dc.contributor.affiliatedAuthor | Heese, Klaus | - |
dc.identifier.doi | 10.2174/1874091X01206010056 | - |
dc.identifier.scopusid | 2-s2.0-84863787837 | - |
dc.identifier.bibliographicCitation | The Open Biochemistry Journal, v.6, pp.56 - 65 | - |
dc.relation.isPartOf | The Open Biochemistry Journal | - |
dc.citation.title | The Open Biochemistry Journal | - |
dc.citation.volume | 6 | - |
dc.citation.startPage | 56 | - |
dc.citation.endPage | 65 | - |
dc.type.rims | ART | - |
dc.type.docType | 정기학술지(Article(Perspective Article포함)) | - |
dc.description.journalClass | 1 | - |
dc.description.isOpenAccess | Y | - |
dc.description.journalRegisteredClass | scopus | - |
dc.subject.keywordPlus | acetylcholine | - |
dc.subject.keywordPlus | actin | - |
dc.subject.keywordPlus | Chinese drug | - |
dc.subject.keywordPlus | desmin | - |
dc.subject.keywordPlus | fibulin 5 | - |
dc.subject.keywordPlus | lipocortin 2 | - |
dc.subject.keywordPlus | phenylephrine | - |
dc.subject.keywordPlus | potassium chloride | - |
dc.subject.keywordPlus | tianma | - |
dc.subject.keywordPlus | unclassified drug | - |
dc.subject.keywordPlus | vasodilator agent | - |
dc.subject.keywordPlus | animal cell | - |
dc.subject.keywordPlus | animal experiment | - |
dc.subject.keywordPlus | animal tissue | - |
dc.subject.keywordPlus | artery compliance | - |
dc.subject.keywordPlus | artery constriction | - |
dc.subject.keywordPlus | artery endothelium | - |
dc.subject.keywordPlus | article | - |
dc.subject.keywordPlus | blood vessel tone | - |
dc.subject.keywordPlus | chronic drug administration | - |
dc.subject.keywordPlus | controlled study | - |
dc.subject.keywordPlus | down regulation | - |
dc.subject.keywordPlus | Gastrodia elata | - |
dc.subject.keywordPlus | male | - |
dc.subject.keywordPlus | nonhuman | - |
dc.subject.keywordPlus | priority journal | - |
dc.subject.keywordPlus | protein expression | - |
dc.subject.keywordPlus | protein metabolism | - |
dc.subject.keywordPlus | rat | - |
dc.subject.keywordPlus | rhizome | - |
dc.subject.keywordPlus | thoracic aorta | - |
dc.subject.keywordPlus | upregulation | - |
dc.subject.keywordPlus | vascular smooth muscle | - |
dc.subject.keywordPlus | vasodilatation | - |
dc.subject.keywordAuthor | Aorta | - |
dc.subject.keywordAuthor | TCM | - |
dc.subject.keywordAuthor | Tianma | - |
dc.subject.keywordAuthor | Vascular disease | - |
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