Genome-wide Evidence of XPC Alteration in Laryngeal Squamous Cell Carcinomas

Abstract

Background: There are discrepancies in data of genome-wide microarray-based comparative genomic hybridization (CGH) in squamous cell carcinoma of the head and neck (SCCHN). Variations in ethnic background, life style, presence of chemotherapy, and regions of SCCHN may explain the results. Methods: Considering the variations, we performed CGH in Korean laryngeal SCC (LSCC) tissues (N=16). Results: We found gains of amplification at 7q35 and 8q24 and losses at 1p21, 2q21, 17q12, and 3p22-26 in 40-50 % of the cases. The regions of losses at 3p22-26 contain no known tumor suppressor gene. However, XPC, a key gene in DNA repair pathway, is identified at 3p22-25. Conclusion: Our finding strongly suggests that chromosome 3p22-p26 region harbor critical gene(s) including XPC associated with risk for LSCC.