Randomized Clinical Trial of Weekly vs. Triweekly Cisplatin-based chemotherapy Concurrent with Radiotherapy in the treatment of locally advanced Cervical Cancer
DC Field | Value | Language |
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dc.contributor.author | Ryu, Sang-Young | - |
dc.contributor.author | Lee, Won Moo | - |
dc.contributor.author | Kim, Kidong | - |
dc.contributor.author | Park, Sang-Il | - |
dc.contributor.author | Kim, Beob-Jong | - |
dc.contributor.author | Kim, Moon-Hong | - |
dc.contributor.author | Choi, Seok-Cheol | - |
dc.contributor.author | Cho, Chul-Koo | - |
dc.contributor.author | Nam, Byung-Ho | - |
dc.contributor.author | Lee, Eui-Don | - |
dc.date.accessioned | 2022-07-16T18:15:25Z | - |
dc.date.available | 2022-07-16T18:15:25Z | - |
dc.date.created | 2021-05-13 | - |
dc.date.issued | 2011-11 | - |
dc.identifier.issn | 0360-3016 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/hanyang/handle/2021.sw.hanyang/167138 | - |
dc.description.abstract | Purpose: To compare compliance, toxicity, and outcome of weekly and triweekly cisplatin administration concurrent with radiotherapy in locally advanced cervical cancer. Methods and Materials: In this open-label, randomized trial, 104 patients with histologically proven Stage IIB-IVA cervical cancer were randomly assigned by a computer-generated procedure to weekly (weekly cisplatin 40 mg/m(2), six cycles) and triweekly (cisplatin 75 mg/m(2) every 3 weeks, three cycles) chemotherapy arms during concurrent radiotherapy. The difference of compliance and the toxicity profiles between the two arms were investigated, and the overall survival rate was analyzed after 5 years. Results: All patients tolerated both treatments very well, with a high completion rate of scheduled chemotherapy cycles. There was no statistically significant difference in compliance between the two arms (86.3% in the weekly arm, 92.5% in the triweekly arm, p > 0.05). Grade 3-4 neutropenia was more frequent in the weekly arm (39.2%) than in the triweekly arm (22.6%) (p = 0.03). The overall 5-year survival rate was significantly higher in the triweekly arm (88.7%) than in the weekly arm (66.5%) (hazard ratio 0.375; 95% confidence interval 0.154-0.914; p = 0.03). Conclusions: Triweekly cisplatin 75-mg/m(2) chemotherapy concurrent with radiotherapy is more effective and feasible than the conventional weekly cisplatin 40-mg/m(2) regimen and may be a strong candidate for the optimal cisplatin dose and dosing schedule in the treatment of locally advanced cervical cancer. | - |
dc.language | 한국어 | - |
dc.language.iso | ko | - |
dc.publisher | ELSEVIER SCIENCE INC | - |
dc.title | Randomized Clinical Trial of Weekly vs. Triweekly Cisplatin-based chemotherapy Concurrent with Radiotherapy in the treatment of locally advanced Cervical Cancer | - |
dc.type | Article | - |
dc.contributor.affiliatedAuthor | Lee, Won Moo | - |
dc.identifier.doi | 10.1016/j.ijrobp.2011.05.002 | - |
dc.identifier.scopusid | 2-s2.0-81155160980 | - |
dc.identifier.wosid | 000309412300050 | - |
dc.identifier.bibliographicCitation | INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS, v.81, no.4, pp.E577 - E581 | - |
dc.relation.isPartOf | INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS | - |
dc.citation.title | INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS | - |
dc.citation.volume | 81 | - |
dc.citation.number | 4 | - |
dc.citation.startPage | E577 | - |
dc.citation.endPage | E581 | - |
dc.type.rims | ART | - |
dc.type.docType | 정기학술지(Article(Perspective Article포함)) | - |
dc.description.journalClass | 1 | - |
dc.description.isOpenAccess | N | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Oncology | - |
dc.relation.journalResearchArea | Radiology, Nuclear Medicine & Medical Imaging | - |
dc.relation.journalWebOfScienceCategory | Oncology | - |
dc.relation.journalWebOfScienceCategory | Radiology, Nuclear Medicine & Medical Imaging | - |
dc.subject.keywordPlus | GYNECOLOGIC-ONCOLOGY-GROUP | - |
dc.subject.keywordPlus | SQUAMOUS-CELL CARCINOMA | - |
dc.subject.keywordPlus | PELVIC RADIATION | - |
dc.subject.keywordPlus | FLUOROURACIL | - |
dc.subject.keywordPlus | METAANALYSIS | - |
dc.subject.keywordPlus | THERAPY | - |
dc.subject.keywordAuthor | Locally advanced cervical cancer | - |
dc.subject.keywordAuthor | Tri-weekly cisplatin-based chemoradiation therapy | - |
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