Carbamazepine-induced severe cutaneous adverse reactions and HLA genotypes in Koreans
DC Field | Value | Language |
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dc.contributor.author | Kim, Sae-Hoon | - |
dc.contributor.author | Lee, Kyung Wha | - |
dc.contributor.author | Song, Woo-Jung | - |
dc.contributor.author | Kim, Sang-Heon | - |
dc.contributor.author | Jee, Young-Koo | - |
dc.contributor.author | Lee, Sang-Min | - |
dc.contributor.author | Kang, Hye-Ryun | - |
dc.contributor.author | Park, Heung-Woo | - |
dc.contributor.author | Cho, Sang-Heon | - |
dc.contributor.author | Park, Seong-Ho | - |
dc.contributor.author | Min, Kyung-Up | - |
dc.contributor.author | Chang, Yoon-Seok | - |
dc.date.accessioned | 2022-07-16T18:20:53Z | - |
dc.date.available | 2022-07-16T18:20:53Z | - |
dc.date.created | 2021-05-12 | - |
dc.date.issued | 2011-11 | - |
dc.identifier.issn | 0920-1211 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/hanyang/handle/2021.sw.hanyang/167214 | - |
dc.description.abstract | Background: Although the US FDA recommends screening for HLA-B*1502 allele in most of Asian ancestry before initiating carbamazepine therapy, the HLA associations with carbamazepine hypersensitivity in non-Chinese Asian populations remain unclear. This study investigated the association between the HLA class I genotype and carbamazepine-induced severe cutaneous adverse reaction (SCAR) in Koreans. Methods: Twenty-four patients who had developed carbamazepine-induced SCAR (7 Stevens-Johnson syndrome (SJS), 17 drug hypersensitivity syndrome (HSS)), 50 carbamazepine-tolerant controls from the Korean Pharmacogenetic Adverse Drug Reaction Research Network and data of 485 Korean general population from a previously published study were recruited. HLA-A, -B, and -C genotyping was performed by direct DNA sequence analysis. Results: Only one of the seven SJS patients was positive for the B*1502 allele, but the frequency of B*1511 was much higher in the patients with CBZ-SJS than in the CBZ-tolerant control patients (P = 0.011, P-c = not significant; OR = 18.0(2.3-141.2)). The frequencies of A*3101 in carbamazepine-induced HSS and SCAR were significantly higher than those in carbamazepine-tolerant controls (P-c = 0.011, OR = 8.8(2.5-30.7) and P-c = 0.013, OR = 7.3(2.3-22.5), respectively). The frequencies of B*1511 in carbamazepine-SJS and A*3101 in carbamazepine-HSS/SCAR were significantly higher than those in the general population. Conclusions: HLA-B*1502 does not seem to be an effective predictive marker for carbamazepine-induced SCAR, while HLA-B*1511 and A*3101 was associated with carbamazepine-induced SJS and HSS/SCAR respectively in the Korean population. | - |
dc.language | 영어 | - |
dc.language.iso | en | - |
dc.publisher | ELSEVIER | - |
dc.title | Carbamazepine-induced severe cutaneous adverse reactions and HLA genotypes in Koreans | - |
dc.type | Article | - |
dc.contributor.affiliatedAuthor | Kim, Sang-Heon | - |
dc.identifier.doi | 10.1016/j.eplepsyres.2011.08.010 | - |
dc.identifier.scopusid | 2-s2.0-81055156142 | - |
dc.identifier.wosid | 000297873800022 | - |
dc.identifier.bibliographicCitation | EPILEPSY RESEARCH, v.97, no.1-2, pp.190 - 197 | - |
dc.relation.isPartOf | EPILEPSY RESEARCH | - |
dc.citation.title | EPILEPSY RESEARCH | - |
dc.citation.volume | 97 | - |
dc.citation.number | 1-2 | - |
dc.citation.startPage | 190 | - |
dc.citation.endPage | 197 | - |
dc.type.rims | ART | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
dc.description.isOpenAccess | N | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Neurosciences & Neurology | - |
dc.relation.journalWebOfScienceCategory | Clinical Neurology | - |
dc.subject.keywordPlus | STEVENS-JOHNSON-SYNDROME | - |
dc.subject.keywordPlus | TOXIC EPIDERMAL NECROLYSIS | - |
dc.subject.keywordPlus | HLA-B-ASTERISK-1502 ALLELE | - |
dc.subject.keywordPlus | CLASS-I | - |
dc.subject.keywordPlus | HYPERSENSITIVITY REACTIONS | - |
dc.subject.keywordPlus | JAPANESE PATIENTS | - |
dc.subject.keywordPlus | RISK-FACTOR | - |
dc.subject.keywordPlus | B LOCUS | - |
dc.subject.keywordPlus | ASSOCIATION | - |
dc.subject.keywordPlus | DIVERSITY | - |
dc.subject.keywordAuthor | Carbamazepine | - |
dc.subject.keywordAuthor | Human leukocyte antigen (HLA) | - |
dc.subject.keywordAuthor | Stevens-Johnson syndrome (SJS) | - |
dc.subject.keywordAuthor | Toxic epidermal necrolysis (TEN) | - |
dc.subject.keywordAuthor | Hypersensitivity syndrome (HSS) | - |
dc.identifier.url | https://www.sciencedirect.com/science/article/pii/S0920121111002348?via%3Dihub | - |
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