Smad4 May Help to Identify a Subset of Colorectal Cancer Patients with Early Recurrence after Curative Therapy
- Authors
- Ahn, Byung Kyu; Jang, Si-Hyong; Paik, Seung Sam; Lee, Kang Hong
- Issue Date
- Nov-2011
- Publisher
- H G E UPDATE MEDICAL PUBLISHING S A
- Keywords
- Smad4; Colorectal cancer; Carcinogenesis; Prognosis
- Citation
- HEPATO-GASTROENTEROLOGY, v.58, no.112, pp.1933 - 1936
- Indexed
- SCIE
SCOPUS
- Journal Title
- HEPATO-GASTROENTEROLOGY
- Volume
- 58
- Number
- 112
- Start Page
- 1933
- End Page
- 1936
- URI
- https://scholarworks.bwise.kr/hanyang/handle/2021.sw.hanyang/167253
- DOI
- 10.5754/hge11186
- ISSN
- 0172-6390
- Abstract
- Background/Aims: Loss of Smad4 function is associated with the acquisition of advanced colorectal cancer phenotypes. We investigated the role of Smad4 as a prognostic marker after curative therapy. Methodology: Four hundred and twenty nine consecutive colorectal cancers were analyzed by tissue microarray-based immunohistochemical assay. Results: Smad4 protein was expressed in 61.5% (24/39), 53.1% (77/145), 41.3% (78/189) and 34.8% (16/46) of stage I, II, III and IV cancers, respectively. Lymphovascular invasion and lymph node metastasis were strongly correlated with the loss of Smad4 expression (p<0.0001 and p=0.002, respectively). Disease-free survival did not differ between Smad4-positive and Smad4-negative cancers. In stage Ill disease, time to recurrence after curative therapy was shorter in the Smad4-negative than in the Smad4-positive cancers (20.1 +/- 15.1 vs. 34.6 +/- 34.1 months, p=0.035). Conclusions: Smad4 protein is of no value in predicting recurrence after curative therapy in colorectal cancer, but it may be helpful in identifying a subset of patients with early recurrence after curative therapy.
- Files in This Item
- There are no files associated with this item.
- Appears in
Collections - 서울 의과대학 > 서울 병리학교실 > 1. Journal Articles
- 서울 의과대학 > 서울 외과학교실 > 1. Journal Articles
![qrcode](https://api.qrserver.com/v1/create-qr-code/?size=55x55&data=https://scholarworks.bwise.kr/hanyang/handle/2021.sw.hanyang/167253)
Items in ScholarWorks are protected by copyright, with all rights reserved, unless otherwise indicated.