LADA prevalence estimation and insulin dependency during follow-up
DC Field | Value | Language |
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dc.contributor.author | Park, Yongsoo | - |
dc.contributor.author | Hong, Sangmo | - |
dc.contributor.author | Park, Leejin | - |
dc.contributor.author | Woo, Jungtaek | - |
dc.contributor.author | Baik, Sehyun | - |
dc.contributor.author | Nam, Munsuk | - |
dc.contributor.author | Lee, Kwanwoo | - |
dc.contributor.author | Kim, Youngseol | - |
dc.date.accessioned | 2022-07-16T18:28:35Z | - |
dc.date.available | 2022-07-16T18:28:35Z | - |
dc.date.created | 2021-05-11 | - |
dc.date.issued | 2011-11 | - |
dc.identifier.issn | 1520-7552 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/hanyang/handle/2021.sw.hanyang/167292 | - |
dc.description.abstract | Background Latent autoimmune diabetes in adults (LADA) is a form of autoimmune-mediated diabetes in adults, usually defined by GAD autoantibody positivity. Few epidemiological surveys on LADA in Asians did not come to a conclusive answer regarding prevalence and incidence, because of different criteria used in patient ascertainment. Methods We estimated LADA prevalence in a recent type 2 diabetes cohort by the positivity of circulating autoantibodies to pancreatic islet cell antigens (GAD, IA-2 and zinc transporter 8 (ZnT8)) applying a comparable Caucasian criteria. We then observed the development of insulin dependency prospectively for 36 months. Results Applying the European NIRAD LADA group criteria, we found a high prevalence of LADA (4.4%) in Korean patients with phenotypic type 2 diabetes. This high prevalence of LADA in Korea is noteworthy since the previous population-based LADA prevalence survey reported low prevalence (1.7%). When we consider the low-titre GAD antibodies and the low prevalence of multiple autoantibodies, however, increased LADA prevalence does not necessarily mean increase in future insulin dependency. After 36 months of follow-up, only 3 of 39 patients who were initially classified as LADA have become insulin-dependent. Those three were all positive for multiple autoantibodies (GAD, IA-2 and zinc transporter 8 antibody). Other features of insulin secretion or insulin resistance did not determine future insulin necessity. Conclusions Although the LADA prevalence estimated by anti-GAD positivity appeared to increase, the true insulin dependency evidenced by multiple antibody positivity did not increase in Korea. | - |
dc.language | 영어 | - |
dc.language.iso | en | - |
dc.publisher | WILEY | - |
dc.title | LADA prevalence estimation and insulin dependency during follow-up | - |
dc.type | Article | - |
dc.contributor.affiliatedAuthor | Hong, Sangmo | - |
dc.identifier.doi | 10.1002/dmrr.1278 | - |
dc.identifier.scopusid | 2-s2.0-80855131131 | - |
dc.identifier.wosid | 000300108000047 | - |
dc.identifier.bibliographicCitation | DIABETES-METABOLISM RESEARCH AND REVIEWS, v.27, no.8, pp.975 - 979 | - |
dc.relation.isPartOf | DIABETES-METABOLISM RESEARCH AND REVIEWS | - |
dc.citation.title | DIABETES-METABOLISM RESEARCH AND REVIEWS | - |
dc.citation.volume | 27 | - |
dc.citation.number | 8 | - |
dc.citation.startPage | 975 | - |
dc.citation.endPage | 979 | - |
dc.type.rims | ART | - |
dc.type.docType | Article; Proceedings Paper | - |
dc.description.journalClass | 1 | - |
dc.description.isOpenAccess | N | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Endocrinology & Metabolism | - |
dc.relation.journalWebOfScienceCategory | Endocrinology & Metabolism | - |
dc.subject.keywordPlus | GLUTAMIC-ACID DECARBOXYLASE | - |
dc.subject.keywordPlus | AUTOIMMUNE DIABETES-MELLITUS | - |
dc.subject.keywordPlus | ADULTS LADA | - |
dc.subject.keywordPlus | ANTIBODIES | - |
dc.subject.keywordPlus | GAD | - |
dc.subject.keywordPlus | AUTOANTIBODIES | - |
dc.subject.keywordPlus | POPULATION | - |
dc.subject.keywordPlus | PREDICTION | - |
dc.subject.keywordPlus | TITERS | - |
dc.subject.keywordPlus | ONSET | - |
dc.subject.keywordAuthor | LADA | - |
dc.subject.keywordAuthor | prevalence | - |
dc.subject.keywordAuthor | incidence | - |
dc.subject.keywordAuthor | insulin dependency | - |
dc.subject.keywordAuthor | multiple autoantibody positivity | - |
dc.identifier.url | https://onlinelibrary.wiley.com/doi/10.1002/dmrr.1278 | - |
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