Voxel-Based Analysis of Diffusion Tensor Imaging in Patients with Subcortical Vascular Cognitive Impairment: Correlates with Cognitive and Motor Deficits
DC Field | Value | Language |
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dc.contributor.author | Kim, Sook Hui | - |
dc.contributor.author | Park, Jun Sung | - |
dc.contributor.author | Ahn, Hyun-Jung | - |
dc.contributor.author | Seo, Sang Won | - |
dc.contributor.author | Lee, Jong-Min | - |
dc.contributor.author | Kim, Sung Tae | - |
dc.contributor.author | Han, Seol-Heui | - |
dc.contributor.author | Na, Duk L. | - |
dc.date.accessioned | 2022-07-16T18:51:43Z | - |
dc.date.available | 2022-07-16T18:51:43Z | - |
dc.date.created | 2021-05-12 | - |
dc.date.issued | 2011-10 | - |
dc.identifier.issn | 1051-2284 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/hanyang/handle/2021.sw.hanyang/167467 | - |
dc.description.abstract | BACKGROUND AND PURPOSE Patients with small vessel disease show high-signal intensity on T2-weighted magnetic resonance (MR) images that represent ischemic cell damage. However, despite a similar degree of ischemic change, the amount and the severity of clinical presentations may vary. We investigated the clinical correlations of ischemic changes using voxel-based morphometric analyses of diffusion tensor imaging (DTI). METHODS Twenty-seven MCI and 34 dementia patients were included who all had significant small vessel disease on magnetic resonance imaging (MRI). In all patients, neuropsychological tests, a rating on the Pyramidal and Extrapyramidal scale (PEPS) for motor deficits, and 3-Tesla MRI including DTI scans were performed. Voxel-based analysis of the fractional anisotropy and mean diffusivity maps were computed. RESULTS Cognitive scores correlated with the DTI abnormalities in supratentorial areas with regional specificity according to each cognitive test. Unexpectedly, cognitive deficits in most neuropsychological tests, even in some frontal tasks, were associated with disruption of posterior white matter integrities. Motor deficits correlated with both supra-and infratentorial lesions. CONCLUSION Our findings suggest that in patients with small vessel disease who show cognitive and motor impairments, a specific distribution of fiber tract damage is more related with clinical deficits than is the severity of the total ischemia. | - |
dc.language | 영어 | - |
dc.language.iso | en | - |
dc.publisher | WILEY | - |
dc.title | Voxel-Based Analysis of Diffusion Tensor Imaging in Patients with Subcortical Vascular Cognitive Impairment: Correlates with Cognitive and Motor Deficits | - |
dc.type | Article | - |
dc.contributor.affiliatedAuthor | Lee, Jong-Min | - |
dc.identifier.doi | 10.1111/j.1552-6569.2010.00527.x | - |
dc.identifier.scopusid | 2-s2.0-80053577161 | - |
dc.identifier.wosid | 000295970700005 | - |
dc.identifier.bibliographicCitation | JOURNAL OF NEUROIMAGING, v.21, no.4, pp.317 - 324 | - |
dc.relation.isPartOf | JOURNAL OF NEUROIMAGING | - |
dc.citation.title | JOURNAL OF NEUROIMAGING | - |
dc.citation.volume | 21 | - |
dc.citation.number | 4 | - |
dc.citation.startPage | 317 | - |
dc.citation.endPage | 324 | - |
dc.type.rims | ART | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
dc.description.isOpenAccess | N | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Neurosciences & Neurology | - |
dc.relation.journalResearchArea | Radiology, Nuclear Medicine & Medical Imaging | - |
dc.relation.journalWebOfScienceCategory | Clinical Neurology | - |
dc.relation.journalWebOfScienceCategory | Neuroimaging | - |
dc.relation.journalWebOfScienceCategory | Radiology, Nuclear Medicine & Medical Imaging | - |
dc.subject.keywordPlus | WHITE-MATTER HYPERINTENSITIES | - |
dc.subject.keywordPlus | SMALL VESSEL DISEASE | - |
dc.subject.keywordPlus | ALZHEIMERS-DISEASE | - |
dc.subject.keywordPlus | SIGNAL HYPERINTENSITIES | - |
dc.subject.keywordPlus | ISCHEMIC LEUKOARAIOSIS | - |
dc.subject.keywordPlus | CHOLINERGIC PATHWAYS | - |
dc.subject.keywordPlus | CORPUS-CALLOSUM | - |
dc.subject.keywordPlus | BRAIN IMAGES | - |
dc.subject.keywordPlus | DEMENTIA | - |
dc.subject.keywordPlus | MRI | - |
dc.subject.keywordAuthor | Subcortical vascular cognitive impairment | - |
dc.subject.keywordAuthor | diffusion tensor imaging | - |
dc.identifier.url | https://onlinelibrary.wiley.com/doi/10.1111/j.1552-6569.2010.00527.x | - |
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