Stimulation of dendritic cells with Helicobacter pylori vacuolating cytotoxin negatively regulates their maturation via the restoration of E2F1
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Kim, J. M. | - |
dc.contributor.author | Kim, J. S. | - |
dc.contributor.author | Yoo, D. Y. | - |
dc.contributor.author | Ko, S. H. | - |
dc.contributor.author | Kim, N. | - |
dc.contributor.author | Kim, H. | - |
dc.contributor.author | Kim, Y. -J. | - |
dc.date.accessioned | 2022-07-16T18:52:58Z | - |
dc.date.available | 2022-07-16T18:52:58Z | - |
dc.date.created | 2021-05-12 | - |
dc.date.issued | 2011-10 | - |
dc.identifier.issn | 0009-9104 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/hanyang/handle/2021.sw.hanyang/167479 | - |
dc.description.abstract | Helicobacter pylori induces an infiltration of dendritic cells (DCs) into the infected gastric mucosa. Although DCs play an important role in the regulation of inflammation, the effects of H. pylori vacuolating cytotoxin (VacA) on DC maturation process have not yet been elucidated. The role of VacA in DC maturation following co-exposure to Escherichia coli lipopolysaccharide (LPS) was investigated. The treatment of immature DCs with LPS up-regulated the expression of surface molecules [e.g. CD40, CD80, CD86 and major histocompatibility complex (MHC) class II], as well as the production of cytokines [e. g. interleukin (IL)-1 beta, IL-12p70 and tumour necrosis gactor (TNF)-alpha] compared with those of unstimulated controls. Co-stimulation with H. pylori VacA significantly reduced the up-regulated DC maturation markers induced by LPS. In addition, VacA sustained the immature state of DCs with high endocytosis and low migratory capacity. The LPS-induced down-regulation of E2F1 expression in DCs was recovered by co-stimulation with VacA. Moreover, suppression of E2F1 by small interfering RNA resulted in a significant recovery of the inhibited DC maturation by VacA. In contrast, VacA did not affect nuclear factor (NF)-kappa B responses to LPS and the NF-kappa B signal was not associated with VacA-induced inhibition of DC maturation. These results suggest that the exposure of DCs to H. pylori VacA negatively regulates DC maturation via the restoration of E2F1. The immunomodulatory action of VacA on DCs may contribute to the ability of VacA-producing H. pylori to establish a persistent infection in the gastric mucosa. | - |
dc.language | 영어 | - |
dc.language.iso | en | - |
dc.publisher | WILEY | - |
dc.title | Stimulation of dendritic cells with Helicobacter pylori vacuolating cytotoxin negatively regulates their maturation via the restoration of E2F1 | - |
dc.type | Article | - |
dc.contributor.affiliatedAuthor | Kim, J. M. | - |
dc.identifier.doi | 10.1111/j.1365-2249.2011.04447.x | - |
dc.identifier.scopusid | 2-s2.0-80052635374 | - |
dc.identifier.wosid | 000294913700004 | - |
dc.identifier.bibliographicCitation | CLINICAL AND EXPERIMENTAL IMMUNOLOGY, v.166, no.1, pp.34 - 45 | - |
dc.relation.isPartOf | CLINICAL AND EXPERIMENTAL IMMUNOLOGY | - |
dc.citation.title | CLINICAL AND EXPERIMENTAL IMMUNOLOGY | - |
dc.citation.volume | 166 | - |
dc.citation.number | 1 | - |
dc.citation.startPage | 34 | - |
dc.citation.endPage | 45 | - |
dc.type.rims | ART | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
dc.description.isOpenAccess | N | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Immunology | - |
dc.relation.journalWebOfScienceCategory | Immunology | - |
dc.subject.keywordPlus | NF-KAPPA-B | - |
dc.subject.keywordPlus | INTESTINAL EPITHELIAL-CELLS | - |
dc.subject.keywordPlus | BACTEROIDES-FRAGILIS ENTEROTOXIN | - |
dc.subject.keywordPlus | TRANSCRIPTION FACTOR | - |
dc.subject.keywordPlus | IMMUNE-RESPONSE | - |
dc.subject.keywordPlus | T-LYMPHOCYTE | - |
dc.subject.keywordPlus | TOXIN VACA | - |
dc.subject.keywordPlus | ACTIVATION | - |
dc.subject.keywordPlus | EXPRESSION | - |
dc.subject.keywordPlus | INFECTION | - |
dc.subject.keywordAuthor | dendritic cells | - |
dc.subject.keywordAuthor | E2F1 | - |
dc.subject.keywordAuthor | H. pylori vacuolating cytotoxin | - |
dc.subject.keywordAuthor | maturation | - |
Items in ScholarWorks are protected by copyright, with all rights reserved, unless otherwise indicated.
222, Wangsimni-ro, Seongdong-gu, Seoul, 04763, Korea+82-2-2220-1365
COPYRIGHT © 2021 HANYANG UNIVERSITY.
Certain data included herein are derived from the © Web of Science of Clarivate Analytics. All rights reserved.
You may not copy or re-distribute this material in whole or in part without the prior written consent of Clarivate Analytics.