Monitoring Processes for the Heat-Induced Crystallization of Heptakis(2,6-di-O-methyl)-beta-cyclodextrin in Water

Abstract

Although some structural analyses of heptakis(2,6-di-O-methyl)-beta-cyclodextrin hydrates have been well conducted, little has been known about processes for the crystallization of this molecule in water upon heating. This study first monitors processes for the heat-induced crystallization of heptakis(2,6-di-O-methyl)-beta-cyclodextrin in water from a dynamic thermal analysis. Results showed that the crystallization is induced by slow dehydration of water molecules from DM-beta-CD molecules, and this process is followed by the fast crystallization of DM-beta-CD molecules.