Effects of granulocyte-colony stimulating factor (G-CSF) on diabetic cardiomyopathy in Otsuka Long-Evans Tokushima Fatty rats
DC Field | Value | Language |
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dc.contributor.author | Lim, Young-Hyo | - |
dc.contributor.author | Joe, Jun-Ho | - |
dc.contributor.author | Jang, Ki-Seok | - |
dc.contributor.author | Song, Yi-Sun | - |
dc.contributor.author | So, Byung-Im | - |
dc.contributor.author | Fang, Cheng-Hu | - |
dc.contributor.author | Shin, Jinho | - |
dc.contributor.author | Kim, Jung-Hyun | - |
dc.contributor.author | Lim, Heon-Kil | - |
dc.contributor.author | Kim, Kyung-Soo | - |
dc.date.accessioned | 2022-07-16T18:57:37Z | - |
dc.date.available | 2022-07-16T18:57:37Z | - |
dc.date.created | 2021-05-12 | - |
dc.date.issued | 2011-10 | - |
dc.identifier.issn | 1475-2840 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/hanyang/handle/2021.sw.hanyang/167524 | - |
dc.description.abstract | Background: Diabetic cardiomyopathy (CMP) is a common and disabling disease in diabetic patients, however no effective treatments have been developed. Although granulocyte-colony stimulating factor (G-CSF) improves heart function in myocardial infarction, its effect on non-ischemic CMP such as diabetic CMP is unknown. In the present study, we investigated the effects of G-CSF on diabetic CMP in a rat model of type II diabetes. Methods: Twenty 7-week-old male Otsuka Long-Evans Tokushima Fatty (OLETF: a rat model of diabetes) rats and 10 male Long-Evans Tokushima Otsuka (LETO: normal controls) rats were used. All of the LETO and 8 OLETF rats were fed on tap water while the rest were fed on sucrose-containing water. After 10 weeks, saline or recombinant human G-CSF (100 mu g/kg/day) was injected intraperitoneally for 5 days. Blood levels of glucose, total cholesterol and triglyceride, and Doppler echocardiograms for diastolic dysfunction were obtained just before and 4 weeks after the saline or G-CSF treatment. Light microscopy, electron microscopy (EM) and immunohistochemistry for transforming growth factor-beta were employed to examine myocardial histology 4 weeks after the saline or G-CSF treatment. Results: Diastolic dysfunction developed at 17 weeks (before the saline or G-CSF treatment) in the OLETF rats whether or not they were fed sucrose water, but were more severe in those fed sucrose water. Four weeks after saline or G-CSF treatment, diastolic function had recovered in the G-CSF-treated group regardless of sucrose water feeding, and perivascular and/or interstitial fibrosis in the G-CSF-treated group had decreased significantly. TGF-beta immunoreactivity in the interstitial and perivascular tissue was also reduced in the G-CSF-treated group, and EM studies revealed less severe disruption of myofilaments and mitochondrial cristae, and decreased collagen deposition. Conclusions: G-CSF can ameliorate cardiac diastolic dysfunction and morphological damage, especially fibrosis of the myocardium, in OLETF rats with diabetic CMP. | - |
dc.language | 영어 | - |
dc.language.iso | en | - |
dc.publisher | BIOMED CENTRAL LTD | - |
dc.title | Effects of granulocyte-colony stimulating factor (G-CSF) on diabetic cardiomyopathy in Otsuka Long-Evans Tokushima Fatty rats | - |
dc.type | Article | - |
dc.contributor.affiliatedAuthor | Lim, Young-Hyo | - |
dc.contributor.affiliatedAuthor | Jang, Ki-Seok | - |
dc.contributor.affiliatedAuthor | Shin, Jinho | - |
dc.identifier.doi | 10.1186/1475-2840-10-92 | - |
dc.identifier.scopusid | 2-s2.0-80054053514 | - |
dc.identifier.wosid | 000297060900001 | - |
dc.identifier.bibliographicCitation | CARDIOVASCULAR DIABETOLOGY, v.10, pp.1 - 10 | - |
dc.relation.isPartOf | CARDIOVASCULAR DIABETOLOGY | - |
dc.citation.title | CARDIOVASCULAR DIABETOLOGY | - |
dc.citation.volume | 10 | - |
dc.citation.startPage | 1 | - |
dc.citation.endPage | 10 | - |
dc.type.rims | ART | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
dc.description.isOpenAccess | Y | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Cardiovascular System & Cardiology | - |
dc.relation.journalResearchArea | Endocrinology & Metabolism | - |
dc.relation.journalWebOfScienceCategory | Cardiac & Cardiovascular Systems | - |
dc.relation.journalWebOfScienceCategory | Endocrinology & Metabolism | - |
dc.subject.keywordPlus | BONE-MARROW-CELLS | - |
dc.subject.keywordPlus | DIASTOLIC DYSFUNCTION | - |
dc.subject.keywordPlus | MYOCARDIAL-INFARCTION | - |
dc.subject.keywordPlus | GLUCOSE-TRANSPORT | - |
dc.subject.keywordPlus | CARDIAC-FUNCTION | - |
dc.subject.keywordPlus | MELLITUS | - |
dc.subject.keywordPlus | PREVALENCE | - |
dc.subject.keywordPlus | CARDIOMYOCYTES | - |
dc.subject.keywordPlus | EXPRESSION | - |
dc.subject.keywordPlus | RECEPTOR | - |
dc.subject.keywordAuthor | Diabetes Mellitus | - |
dc.subject.keywordAuthor | Cardiomyopathy | - |
dc.subject.keywordAuthor | Echocardiography | - |
dc.subject.keywordAuthor | Doppler | - |
dc.subject.keywordAuthor | Histology | - |
dc.subject.keywordAuthor | Fibrosis | - |
dc.identifier.url | https://cardiab.biomedcentral.com/articles/10.1186/1475-2840-10-92 | - |
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