Change of telomerase activity in peripheral whole blood of head and neck squamous cell carcinoma patients before and after surgery: a pilot study
DC Field | Value | Language |
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dc.contributor.author | Lee, Yong Seop | - |
dc.contributor.author | Tae, Kyung | - |
dc.contributor.author | Lee, Seung Hwan | - |
dc.contributor.author | Cho, Seok Hyun | - |
dc.contributor.author | Jeong, Jin Hyeok | - |
dc.contributor.author | Min, Hyun Jung | - |
dc.contributor.author | Ji, Yong Bae | - |
dc.date.accessioned | 2022-07-16T18:58:45Z | - |
dc.date.available | 2022-07-16T18:58:45Z | - |
dc.date.created | 2021-05-11 | - |
dc.date.issued | 2011-10 | - |
dc.identifier.issn | 1699-048X | - |
dc.identifier.uri | https://scholarworks.bwise.kr/hanyang/handle/2021.sw.hanyang/167534 | - |
dc.description.abstract | Background The purpose of this study was to evaluate telomerase activity in peripheral whole blood from head and neck squamous cell carcinoma (HNSCC) patients as a biomarker for diagnosis of HNSCC or detection of recurrence during follow-up. Materials and methods Telomerase activity was measured from peripheral whole blood extracts by telomerase repeat amplification protocol (TRAP) in HNSCC patients before and after surgery and in a control group. Sixty-two HNSCC patients and 42 control subjects were included. Results Telomerase activity was found in 41 out of 62 (66.1%) HNSCC patients before surgery and in 8 out of 42 (19.0%) controls (p<0.001). Among 41 HNSCC patients who showed positive telomerase activity before surgery, 32 (78.1%) showed a conversion of telomerase activity to negative after surgery. In follow-up, 6 out of 8 (75%) showed conversion of telomerase activity from negative to positive after recurrence. Telomerase activity was changed to negative in 4 out of 6 (66%) recurred patients with positive telomerase activity after second surgery. Conclusion The telomerase activity in peripheral whole blood extracts of HNSCC patients might be a useful biomarker for detecting recurrence after treatment. Further study with larger sample size using a more sensitive detection method of telomerase activity is necessary to verify these results. | - |
dc.language | 영어 | - |
dc.language.iso | en | - |
dc.publisher | SPRINGER | - |
dc.title | Change of telomerase activity in peripheral whole blood of head and neck squamous cell carcinoma patients before and after surgery: a pilot study | - |
dc.type | Article | - |
dc.contributor.affiliatedAuthor | Tae, Kyung | - |
dc.contributor.affiliatedAuthor | Lee, Seung Hwan | - |
dc.contributor.affiliatedAuthor | Cho, Seok Hyun | - |
dc.contributor.affiliatedAuthor | Jeong, Jin Hyeok | - |
dc.identifier.doi | 10.1007/s12094-011-0727-5 | - |
dc.identifier.scopusid | 2-s2.0-81255214780 | - |
dc.identifier.wosid | 000297553700010 | - |
dc.identifier.bibliographicCitation | CLINICAL & TRANSLATIONAL ONCOLOGY, v.13, no.10, pp.747 - 752 | - |
dc.relation.isPartOf | CLINICAL & TRANSLATIONAL ONCOLOGY | - |
dc.citation.title | CLINICAL & TRANSLATIONAL ONCOLOGY | - |
dc.citation.volume | 13 | - |
dc.citation.number | 10 | - |
dc.citation.startPage | 747 | - |
dc.citation.endPage | 752 | - |
dc.type.rims | ART | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
dc.description.isOpenAccess | N | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Oncology | - |
dc.relation.journalWebOfScienceCategory | Oncology | - |
dc.subject.keywordPlus | MOLECULAR-DETECTION | - |
dc.subject.keywordPlus | MONONUCLEAR-CELLS | - |
dc.subject.keywordPlus | THYROID-NODULES | - |
dc.subject.keywordPlus | CANCER PATIENTS | - |
dc.subject.keywordPlus | ACTIVATION | - |
dc.subject.keywordPlus | LYMPHOCYTES | - |
dc.subject.keywordPlus | EXPRESSION | - |
dc.subject.keywordPlus | DIAGNOSIS | - |
dc.subject.keywordPlus | RNA | - |
dc.subject.keywordAuthor | Telomerase | - |
dc.subject.keywordAuthor | Head and neck cancer | - |
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