A Mechanism for the Action of the Compound DA-6034 on NF-kappa B Pathway Activation in Helicobacter pylori-Infected Gastric Epithelial Cells
DC Field | Value | Language |
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dc.contributor.author | Ko, S. H. | - |
dc.contributor.author | Yoo, D. Y. | - |
dc.contributor.author | Kim, Y-J. | - |
dc.contributor.author | Choi, S. M. | - |
dc.contributor.author | Kang, K. K. | - |
dc.contributor.author | Kim, H. | - |
dc.contributor.author | Kim, N. | - |
dc.contributor.author | Kim, J. S. | - |
dc.contributor.author | Kim, Jung Mogg | - |
dc.date.accessioned | 2022-07-16T19:08:50Z | - |
dc.date.available | 2022-07-16T19:08:50Z | - |
dc.date.created | 2021-05-12 | - |
dc.date.issued | 2011-09 | - |
dc.identifier.issn | 0300-9475 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/hanyang/handle/2021.sw.hanyang/167661 | - |
dc.description.abstract | DA-6034 is a synthetic derivative of eupatilin, a flavonoid with anti-inflammatory effects. The aim of this study was to investigate the effects of DA-6034 on the interactions between I kappa B kinase (IKK) and heat shock protein 90 (Hsp90), and activation of the nuclear factor-kappaB (NF-kappa B) signalling pathway in human gastric epithelial cells infected with Helicobacter pylori. MKN-45 gastric epithelial cell line was treated with DA-6034 and H. pylori. DA-6034 significantly inhibited NF-kappa B activation and upregulated the expressions of interleukin-8 (IL-8) and monocyte chemoattractant protein-1 in MKN-45 cells infected with H. pylori. However, DA-6034 did not influence activator protein-1 DNA binding activity in H. pylori-infected gastric epithelial cells. Pretreatment with DA-6034 attenuated the H. pylori-induced increase in IKK activity, and Hsp90 was associated with IKK-alpha and IKK-gamma in MKN-45 cells. Treatment with DA-6034 dissociated the Hsp90 and IKK-gamma complex in H. pylori-infected cells, leading to the inhibition of IL-8 expression. These results suggest that the eupatilin derivative 7-carboxymethyloxy-3',4',5-trimethoxy flavone has anti-inflammatory activity in gastric epithelial cells infected with H. pylori through the promotion of the dissociation of the IKK-gamma-Hsp90 complex and suppression of NF-kappa B signalling. | - |
dc.language | 영어 | - |
dc.language.iso | en | - |
dc.publisher | WILEY-BLACKWELL | - |
dc.title | A Mechanism for the Action of the Compound DA-6034 on NF-kappa B Pathway Activation in Helicobacter pylori-Infected Gastric Epithelial Cells | - |
dc.type | Article | - |
dc.contributor.affiliatedAuthor | Kim, Jung Mogg | - |
dc.identifier.doi | 10.1111/j.1365-3083.2011.02577.x | - |
dc.identifier.scopusid | 2-s2.0-79961100785 | - |
dc.identifier.wosid | 000293635900005 | - |
dc.identifier.bibliographicCitation | SCANDINAVIAN JOURNAL OF IMMUNOLOGY, v.74, no.3, pp.253 - 263 | - |
dc.relation.isPartOf | SCANDINAVIAN JOURNAL OF IMMUNOLOGY | - |
dc.citation.title | SCANDINAVIAN JOURNAL OF IMMUNOLOGY | - |
dc.citation.volume | 74 | - |
dc.citation.number | 3 | - |
dc.citation.startPage | 253 | - |
dc.citation.endPage | 263 | - |
dc.type.rims | ART | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
dc.description.isOpenAccess | N | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Immunology | - |
dc.relation.journalWebOfScienceCategory | Immunology | - |
dc.subject.keywordPlus | BACTEROIDES-FRAGILIS ENTEROTOXIN | - |
dc.subject.keywordPlus | CLOSTRIDIUM-DIFFICILE TOXIN | - |
dc.subject.keywordPlus | PROTEIN-KINASE | - |
dc.subject.keywordPlus | CHEMOATTRACTANT PROTEIN-1 | - |
dc.subject.keywordPlus | VACUOLATING CYTOTOXIN | - |
dc.subject.keywordPlus | CHEMOKINE EXPRESSION | - |
dc.subject.keywordPlus | SIGNALING PATHWAY | - |
dc.subject.keywordPlus | HSP90 COMPLEX | - |
dc.subject.keywordPlus | IKK-GAMMA | - |
dc.subject.keywordPlus | INFLAMMATION | - |
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