The CDG1 Kinase Mediates Brassinosteroid Signal Transduction from BRI1 Receptor Kinase to BSU1 Phosphatase and GSK3-like Kinase BIN2
DC Field | Value | Language |
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dc.contributor.author | Kim, Tae Wuk | - |
dc.contributor.author | Guan, Shenheng | - |
dc.contributor.author | Burlingame, Alma L. | - |
dc.contributor.author | Wang, Zhi-Yong | - |
dc.date.accessioned | 2022-07-16T19:18:57Z | - |
dc.date.available | 2022-07-16T19:18:57Z | - |
dc.date.created | 2021-05-13 | - |
dc.date.issued | 2011-08 | - |
dc.identifier.issn | 1097-2765 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/hanyang/handle/2021.sw.hanyang/167736 | - |
dc.description.abstract | The brassinosteroid (BR) signaling pathway includes two receptor-like kinases (BRI1 and BAK1), a plasma membrane-associated kinase (BSK1), two phosphatases (BSU1 and PP2A), a GSK3-like kinase (BIN2), and two homologous transcription factors (BZR1 and BES1/BZR2). But the mechanisms of signal relay are not fully understood. Here, we show that a receptor-like cytoplasmic kinase named CDG1 mediates signal transduction from BRI1 to BSU1. Transgenic experiments confirm that CDG1 and its homolog CDL1 positively regulate BR signaling and plant growth. Mass spectrometry analysis identified BRI1 phosphorylation sites in CDG1 and CDG1 phosphorylation sites in BSU1. Mutations of these phosphorylation sites compromised the BR signaling functions. The results demonstrate that BRI1 phosphorylates S234 to activate CDG1 kinase, and CDG1 in turn phosphorylates S764 to activate BSU1, which inactivates BIN2 by dephosphorylating Y200 of BIN2. This study thus demonstrates a complete phosphorylation/dephosphorylation cascade linking a steroid-activated receptor kinase to a GSK3-like kinase in plants. | - |
dc.language | 영어 | - |
dc.language.iso | en | - |
dc.publisher | Cell Press | - |
dc.title | The CDG1 Kinase Mediates Brassinosteroid Signal Transduction from BRI1 Receptor Kinase to BSU1 Phosphatase and GSK3-like Kinase BIN2 | - |
dc.type | Article | - |
dc.contributor.affiliatedAuthor | Kim, Tae Wuk | - |
dc.identifier.doi | 10.1016/j.molcel.2011.05.037 | - |
dc.identifier.scopusid | 2-s2.0-80051744272 | - |
dc.identifier.wosid | 000294151000009 | - |
dc.identifier.bibliographicCitation | Molecular Cell, v.43, no.4, pp.561 - 571 | - |
dc.relation.isPartOf | Molecular Cell | - |
dc.citation.title | Molecular Cell | - |
dc.citation.volume | 43 | - |
dc.citation.number | 4 | - |
dc.citation.startPage | 561 | - |
dc.citation.endPage | 571 | - |
dc.type.rims | ART | - |
dc.type.docType | 정기학술지(Article(Perspective Article포함)) | - |
dc.description.journalClass | 1 | - |
dc.description.isOpenAccess | Y | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Biochemistry & Molecular Biology | - |
dc.relation.journalResearchArea | Cell Biology | - |
dc.relation.journalWebOfScienceCategory | Biochemistry & Molecular Biology | - |
dc.relation.journalWebOfScienceCategory | Cell Biology | - |
dc.subject.keywordPlus | brassinosteroid | - |
dc.subject.keywordPlus | brl1 enzyme | - |
dc.subject.keywordPlus | bsk1 enzyme | - |
dc.subject.keywordPlus | bsu1 enzyme | - |
dc.subject.keywordPlus | cdg 1 enzyme | - |
dc.subject.keywordPlus | cytoplasmic receptor | - |
dc.subject.keywordPlus | enzyme | - |
dc.subject.keywordPlus | gsk3 like kinase | - |
dc.subject.keywordPlus | membrane protein | - |
dc.subject.keywordPlus | phosphatase | - |
dc.subject.keywordPlus | unclassified drug | - |
dc.identifier.url | https://www.sciencedirect.com/science/article/pii/S1097276511005284?via%3Dihub | - |
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