Bacteroides fragilis Enterotoxin Upregulates Intercellular Adhesion Molecule-1 in Endothelial Cells via an Aldose Reductase-, MAPK-, and NF-kappa B-Dependent Pathway, Leading to Monocyte Adhesion to Endothelial Cells
DC Field | Value | Language |
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dc.contributor.author | Roh, Hyun Cheol | - |
dc.contributor.author | Yoo, Do Young | - |
dc.contributor.author | Ko, Su Hyuk | - |
dc.contributor.author | Kim, Young-Jeon | - |
dc.contributor.author | Kim, Jung Mogg | - |
dc.date.accessioned | 2022-07-16T19:41:57Z | - |
dc.date.available | 2022-07-16T19:41:57Z | - |
dc.date.created | 2021-05-12 | - |
dc.date.issued | 2011-08 | - |
dc.identifier.issn | 0022-1767 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/hanyang/handle/2021.sw.hanyang/167896 | - |
dc.description.abstract | Enterotoxigenic Bacteroides fragilis (ETBF) produces a similar to 20-kDa heat-labile enterotoxin (BFT) that plays an essential role in mucosal inflammation. Although a variety of inflammatory cells is found at ETBF-infected sites, little is known about leukocyte adhesion in response to BFT stimulation. We investigated whether BFT affected the expression of ICAM-1 and monocytic adhesion to endothelial cells (ECs). Stimulation of HUVECs and rat aortic ECs with BFT resulted in the induction of ICAM-1 expression. Upregulation of ICAM-1 was dependent on the activation of I kappa B kinase (IKK) and NF-kappa B signaling. In contrast, suppression of AP-1 did not affect ICAM-1 expression in BFT-stimulated cells. Suppression of NF-kappa B activity in HUVECs significantly reduced monocytic adhesion, indicating that ICAM-1 expression is indispensable for BFT-induced adhesion of monocytes to the endothelium. Inhibition of JNK resulted in a significant attenuation of BFT-induced ICAM-1 expression in ECs. Moreover, inhibition of aldose reductase significantly reduced JNK-dependent IKK/NF-kappa B activation, ICAM-1 expression, and adhesion of monocytes to HUVECs. These results suggest that a signaling pathway involving aldose reductase, JNK, IKK, and NF-kappa B is required for ICAM-1 induction in ECs exposed to BFT, and may be involved in the leukocyte-adhesion cascade following infection with ETBF. The Journal of Immunology, 2011, 187: 1931-1941. | - |
dc.language | 영어 | - |
dc.language.iso | en | - |
dc.publisher | AMER ASSOC IMMUNOLOGISTS | - |
dc.title | Bacteroides fragilis Enterotoxin Upregulates Intercellular Adhesion Molecule-1 in Endothelial Cells via an Aldose Reductase-, MAPK-, and NF-kappa B-Dependent Pathway, Leading to Monocyte Adhesion to Endothelial Cells | - |
dc.type | Article | - |
dc.contributor.affiliatedAuthor | Kim, Jung Mogg | - |
dc.identifier.doi | 10.4049/jimmunol.1101226 | - |
dc.identifier.scopusid | 2-s2.0-80051917514 | - |
dc.identifier.wosid | 000293384600045 | - |
dc.identifier.bibliographicCitation | JOURNAL OF IMMUNOLOGY, v.187, no.4, pp.1931 - 1941 | - |
dc.relation.isPartOf | JOURNAL OF IMMUNOLOGY | - |
dc.citation.title | JOURNAL OF IMMUNOLOGY | - |
dc.citation.volume | 187 | - |
dc.citation.number | 4 | - |
dc.citation.startPage | 1931 | - |
dc.citation.endPage | 1941 | - |
dc.type.rims | ART | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
dc.description.isOpenAccess | N | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Immunology | - |
dc.relation.journalWebOfScienceCategory | Immunology | - |
dc.subject.keywordPlus | INTESTINAL EPITHELIAL-CELLS | - |
dc.subject.keywordPlus | CLOSTRIDIUM-DIFFICILE TOXIN | - |
dc.subject.keywordPlus | ACTIVATED PROTEIN-KINASE | - |
dc.subject.keywordPlus | TRANSCRIPTION FACTORS | - |
dc.subject.keywordPlus | LEUKOCYTE ADHESION | - |
dc.subject.keywordPlus | VCAM-1 EXPRESSION | - |
dc.subject.keywordPlus | SIGNALING PATHWAY | - |
dc.subject.keywordPlus | ICAM-1 EXPRESSION | - |
dc.subject.keywordPlus | INDUCED ENTERITIS | - |
dc.subject.keywordPlus | GENE-EXPRESSION | - |
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