The Clinical Significance of HbA1c as a Predictive Factor for Abnormal Postprandial Glucose Metabolism in NAFLD Patients with an Elevated Liver Chemistry
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Jun, Dae Won | - |
dc.contributor.author | Kim, Hyo Jeong | - |
dc.contributor.author | Bae, June Ho | - |
dc.contributor.author | Lee, Oh Young | - |
dc.date.accessioned | 2022-07-16T19:59:22Z | - |
dc.date.available | 2022-07-16T19:59:22Z | - |
dc.date.created | 2021-05-12 | - |
dc.date.issued | 2011-07 | - |
dc.identifier.issn | 0172-6390 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/hanyang/handle/2021.sw.hanyang/168087 | - |
dc.description.abstract | Background/Aims: NAFLD patients often show normal fasting glucose levels despite having abnormal postprandial glucose levels. This study is aimed at examining the possibility of utilizing HbA1c as a surrogate marker for abnormal glucose tolerance in NAFLD. Methodology: This study was conducted on ninety-one NAFLD patients exhibiting elevated liver enzyme. Oral glucose tolerance tests (OGTT) (75g) were performed. Insulin concentrations were measured in a fasting state, and again at 120 minutes. Results: Sixteen subjects (44.7%) showed abnormal postprandial glucose levels among subjects with normal fasting glucose level (<100mg/dL). Among subjects whose fasting glucose levels were within the 100-125mg/dL range, 30 patients (68.2%) showed abnormal OGTT findings and 13 patients (29.5%) were diagnosed as diabetics. In univariate analysis, the predictive factors for abnormal glucose tolerance were found to be HbA1c, age, fasting glucose and 120-minute insulin. However, in multivariate analysis, only HbA1c was found to be a significant predictive factor ((B)=0.43, p=0.017). The mean values for HbA1c were higher in the diabetes (6.2%) and glucose intolerance groups (5.8%) than in the normal group (5.5%). Using HbA1c 5.8% as the cut-off level in AUROC, sensitivity and specificity for predicting abnormal OGTT were 71.0% and 89.9%. Of NAFLD patients who showed HbA1c concentrations of 5.8% or higher, 90.9% showed abnormal OGTT. Conclusions: In NAFLD patients, an HbA1c concentration of 5.8% or higher can be used as an index for predicting abnormal postprandial glucose tolerance. | - |
dc.language | 영어 | - |
dc.language.iso | en | - |
dc.publisher | H G E UPDATE MEDICAL PUBLISHING S A | - |
dc.title | The Clinical Significance of HbA1c as a Predictive Factor for Abnormal Postprandial Glucose Metabolism in NAFLD Patients with an Elevated Liver Chemistry | - |
dc.type | Article | - |
dc.contributor.affiliatedAuthor | Jun, Dae Won | - |
dc.contributor.affiliatedAuthor | Lee, Oh Young | - |
dc.identifier.doi | 10.5754/hge10729 | - |
dc.identifier.scopusid | 2-s2.0-83355172742 | - |
dc.identifier.wosid | 000297604400039 | - |
dc.identifier.bibliographicCitation | HEPATO-GASTROENTEROLOGY, v.58, no.109, pp.1274 - 1279 | - |
dc.relation.isPartOf | HEPATO-GASTROENTEROLOGY | - |
dc.citation.title | HEPATO-GASTROENTEROLOGY | - |
dc.citation.volume | 58 | - |
dc.citation.number | 109 | - |
dc.citation.startPage | 1274 | - |
dc.citation.endPage | 1279 | - |
dc.type.rims | ART | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
dc.description.isOpenAccess | N | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Gastroenterology & Hepatology | - |
dc.relation.journalResearchArea | Surgery | - |
dc.relation.journalWebOfScienceCategory | Gastroenterology & Hepatology | - |
dc.relation.journalWebOfScienceCategory | Surgery | - |
dc.subject.keywordPlus | FASTING PLASMA-GLUCOSE | - |
dc.subject.keywordPlus | GLYCATED HEMOGLOBIN | - |
dc.subject.keywordPlus | HBA(1C) | - |
dc.subject.keywordPlus | RISK | - |
dc.subject.keywordPlus | ASSOCIATION | - |
dc.subject.keywordPlus | DISEASE | - |
dc.subject.keywordAuthor | Non-alcoholic fatty liver disease | - |
dc.subject.keywordAuthor | HbA1c | - |
dc.subject.keywordAuthor | Glucose intolerance | - |
dc.subject.keywordAuthor | Insulin resistance | - |
Items in ScholarWorks are protected by copyright, with all rights reserved, unless otherwise indicated.
222, Wangsimni-ro, Seongdong-gu, Seoul, 04763, Korea+82-2-2220-1365
COPYRIGHT © 2021 HANYANG UNIVERSITY.
Certain data included herein are derived from the © Web of Science of Clarivate Analytics. All rights reserved.
You may not copy or re-distribute this material in whole or in part without the prior written consent of Clarivate Analytics.