Clinicopathologic significance of serum response factor expression in colorectal adenocarcinomas
DC Field | Value | Language |
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dc.contributor.author | Jang, Se Min | - |
dc.contributor.author | Jun, Young Jin | - |
dc.contributor.author | Han, Hulin | - |
dc.contributor.author | Lee, Kang Hong | - |
dc.contributor.author | Jang, Ki-Seok | - |
dc.contributor.author | Paik, Seung Sam | - |
dc.date.accessioned | 2022-07-16T20:04:59Z | - |
dc.date.available | 2022-07-16T20:04:59Z | - |
dc.date.created | 2021-05-13 | - |
dc.date.issued | 2011-06 | - |
dc.identifier.issn | 1755-9294 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/hanyang/handle/2021.sw.hanyang/168149 | - |
dc.description.abstract | Background and aim: The purpose of this study was to investigate the role of serum response factor (SRF) expression and to evaluate its correlation with various clinicopathological parameters in colorectal adenocarcinomas. Methods: We used tissue microarrays consisting of 24 normal mucosa, 50 tubular adenomas, 496 adenocarcinomas, and 128 metastatic lesions. Results: The expression of SRF was rare in normal colonic mucosa with a mean expression score of 0.67 ± 0.17. Tubular adenomas had a mean expression score of 2.48 ± 0.31, adenocarcinomas 2.82 ± 0.13 and lymph node metastases 2.82 ± 0.36. Interestingly, SRF expression was high in distant metastases with a mean expression score of 4.83 ± 0.43. The mean SRF expression was increased significantly early in the normal-adenoma-carcinoma sequence and again in distant metastases. The positive SRF expression was strongly correlated with non-mucinous tumor type (P < 0.001). Moderately and poorly differentiated adenocarcinomas had higher mean expression scores than well-differentiated adenocarcinomas (2.88 ± 0.13 vs 1.33 ± 0.32) (P= 0.015). There were significant associations between SRF expression and expression of p53 (P= 0.034) and Ki-67 (P= 0.001). Conclusions: Our results suggest that SRF expression may be the early event of normal-adenoma-carcinoma sequence of colorectal cancer, especially in adenomatous change of colonic mucosa and may play an important role in distant metastasis of colorectal cancers. | - |
dc.language | 영어 | - |
dc.language.iso | en | - |
dc.publisher | Wiley - V C H Verlag GmbbH & Co. | - |
dc.title | Clinicopathologic significance of serum response factor expression in colorectal adenocarcinomas | - |
dc.type | Article | - |
dc.contributor.affiliatedAuthor | Lee, Kang Hong | - |
dc.identifier.doi | 10.1111/j.1755-9294.2011.01103.x | - |
dc.identifier.scopusid | 2-s2.0-79958831926 | - |
dc.identifier.bibliographicCitation | BASIC AND APPLIED PATHOLOGY, v.4, no. 2, pp.46 - 52 | - |
dc.relation.isPartOf | BASIC AND APPLIED PATHOLOGY | - |
dc.citation.title | BASIC AND APPLIED PATHOLOGY | - |
dc.citation.volume | 4 | - |
dc.citation.number | 2 | - |
dc.citation.startPage | 46 | - |
dc.citation.endPage | 52 | - |
dc.type.rims | ART | - |
dc.type.docType | 정기학술지(Article(Perspective Article포함)) | - |
dc.description.journalClass | 1 | - |
dc.description.isOpenAccess | N | - |
dc.description.journalRegisteredClass | scopus | - |
dc.subject.keywordAuthor | Adenocarcinoma | - |
dc.subject.keywordAuthor | Colorectum | - |
dc.subject.keywordAuthor | Ki-67 | - |
dc.subject.keywordAuthor | P53 | - |
dc.subject.keywordAuthor | Serum response factor | - |
dc.identifier.url | https://onlinelibrary.wiley.com/doi/10.1111/j.1755-9294.2011.01103.x | - |
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