Structural insight into brassinosteroid perception by BRI1
DC Field | Value | Language |
---|---|---|
dc.contributor.author | She, Ji | - |
dc.contributor.author | Han, Zhifu | - |
dc.contributor.author | Kim, Tae Wuk | - |
dc.contributor.author | Wang, Jinjing | - |
dc.contributor.author | Cheng, Wei | - |
dc.contributor.author | Chang, Junbiao | - |
dc.contributor.author | Shi, Shuai | - |
dc.contributor.author | Wang, Jiawei | - |
dc.contributor.author | Yang, Maojun | - |
dc.contributor.author | Wang, Zhi-Yong | - |
dc.contributor.author | Chai, Jijie | - |
dc.date.accessioned | 2022-07-16T20:06:02Z | - |
dc.date.available | 2022-07-16T20:06:02Z | - |
dc.date.created | 2021-05-13 | - |
dc.date.issued | 2011-06 | - |
dc.identifier.issn | 0028-0836 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/hanyang/handle/2021.sw.hanyang/168165 | - |
dc.description.abstract | Brassinosteroids are essential phytohormones that have crucial roles in plant growth and development. Perception of brassinosteroids requires an active complex of BRASSINOSTEROID-INSENSITIVE 1 (BRI1) and BRI1-ASSOCIATED KINASE 1 (BAK1). Recognized by the extracellular leucine-rich repeat (LRR) domain of BRI1, brassinosteroids induce a phosphorylation-mediated cascade to regulate gene expression. Here we present the crystal structures of BRI1(LRR) in free and brassinolide-bound forms. BRI1(LRR) exists as a monomer in crystals and solution independent of brassinolide. It comprises a helical solenoid structure that accommodates a separate insertion domain at its concave surface. Sandwiched between them, brassinolide binds to a hydrophobicity-dominating surface groove on BRI1(LRR). Brassinolide recognition by BRI1(LRR) is through an induced-fit mechanism involving stabilization of two interdomain loops that creates a pronounced non-polar surface groove for the hormone binding. Together, our results define the molecular mechanisms by which BRI1 recognizes brassinosteroids and provide insight into brassinosteroid-induced BRI1 activation. | - |
dc.language | 영어 | - |
dc.language.iso | en | - |
dc.publisher | Nature Publishing Group | - |
dc.title | Structural insight into brassinosteroid perception by BRI1 | - |
dc.type | Article | - |
dc.contributor.affiliatedAuthor | Kim, Tae Wuk | - |
dc.identifier.doi | 10.1038/nature10178 | - |
dc.identifier.scopusid | 2-s2.0-79959535565 | - |
dc.identifier.wosid | 000291939700040 | - |
dc.identifier.bibliographicCitation | Nature, v.474, no.7352, pp.472 - 477 | - |
dc.relation.isPartOf | Nature | - |
dc.citation.title | Nature | - |
dc.citation.volume | 474 | - |
dc.citation.number | 7352 | - |
dc.citation.startPage | 472 | - |
dc.citation.endPage | 477 | - |
dc.type.rims | ART | - |
dc.type.docType | 정기학술지(Article(Perspective Article포함)) | - |
dc.description.journalClass | 1 | - |
dc.description.isOpenAccess | Y | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Science & Technology - Other Topics | - |
dc.relation.journalWebOfScienceCategory | Multidisciplinary Sciences | - |
dc.subject.keywordPlus | brassinosteroid | - |
dc.subject.keywordPlus | brassinosteroid insensitive 1 | - |
dc.subject.keywordPlus | monomer | - |
dc.subject.keywordPlus | unclassified drug | - |
dc.subject.keywordPlus | vegetable protein | - |
dc.identifier.url | https://www.nature.com/articles/nature10178 | - |
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