Constitutive Overexpression of Id-1 in Mammary Glands of Transgenic Mice Results in Precocious and Increased Formation of Terminal End Buds, Enhanced Alveologenesis, Delayed Involution
DC Field | Value | Language |
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dc.contributor.author | Shin, Dong-Hui | - |
dc.contributor.author | Jang, Si-Hyong | - |
dc.contributor.author | Kang, Byeong-Cheol | - |
dc.contributor.author | Kim, Hyun-Jun | - |
dc.contributor.author | Oh, Seung Hyun | - |
dc.contributor.author | Kong, Gu | - |
dc.date.accessioned | 2022-07-16T20:46:16Z | - |
dc.date.available | 2022-07-16T20:46:16Z | - |
dc.date.created | 2021-05-12 | - |
dc.date.issued | 2011-05 | - |
dc.identifier.issn | 0021-9541 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/hanyang/handle/2021.sw.hanyang/168523 | - |
dc.description.abstract | Inhibitor of differentiation-1 (Id-1) has been shown to play an essential role in cell proliferation, invasion, migration, and anti-apoptosis. However, the effect of Id-1 in mammary gland development remains unknown. Here, we generated MMTV-Id-1 transgenic mice to study the role of Id-1 in mammary gland development. In virgin mice, Id-1 overexpression led to precocious development and delayed regression of terminal end buds (TEBs) compared with wild-type mice. The number of BrdU-positive cells and the expression of Wnt signaling molecules, beta-catenin and cyclin D1, which regulate ductal extension and TEB formation in virgin, were statistically higher in Id-1 transgenic mice than in wild-type mice. Id-1 also had an effect on the formation and proliferation of lobuloalveolar structures during early and mid-pregnancy. Id-1 transgenic mice had more lobulated and prominent alveolar budding than wild-type mice and had significantly greater counts of lobuloalveolar structures in early pregnancy. The expression of BrdU, beta-catenin, and cyclin D1 was also predominantly increased in Id-1 transgenic mice. Moreover, Id-1 transgenic mice showed delayed involution. Id-1 regulated the expression levels of anti-apoptotic Bcl-2 and pro-apoptotic Bax, and resulted in delay of apoptotic peak during postlactational involution. We also found that Id-1 was able to modulate expression of the regulators of Wnt/beta-catenin signaling such as phospho-Akt, BMP2, FGF3, and RAR-beta in tubuloalveolar development of mammary glands. Taken together, our results suggest that Id-1 plays a pivotal role in mammary gland development through Wnt signaling-mediated acceleration of precocity and alveologenesis and Bcl-2 family members-mediated delay of involution. J. Cell. Physiol. 226: 1340-1352, 2011. | - |
dc.language | 영어 | - |
dc.language.iso | en | - |
dc.publisher | WILEY | - |
dc.title | Constitutive Overexpression of Id-1 in Mammary Glands of Transgenic Mice Results in Precocious and Increased Formation of Terminal End Buds, Enhanced Alveologenesis, Delayed Involution | - |
dc.type | Article | - |
dc.contributor.affiliatedAuthor | Kong, Gu | - |
dc.identifier.doi | 10.1002/jcp.22462 | - |
dc.identifier.scopusid | 2-s2.0-79951783572 | - |
dc.identifier.wosid | 000288395500022 | - |
dc.identifier.bibliographicCitation | JOURNAL OF CELLULAR PHYSIOLOGY, v.226, no.5, pp.1340 - 1352 | - |
dc.relation.isPartOf | JOURNAL OF CELLULAR PHYSIOLOGY | - |
dc.citation.title | JOURNAL OF CELLULAR PHYSIOLOGY | - |
dc.citation.volume | 226 | - |
dc.citation.number | 5 | - |
dc.citation.startPage | 1340 | - |
dc.citation.endPage | 1352 | - |
dc.type.rims | ART | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
dc.description.isOpenAccess | N | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Cell Biology | - |
dc.relation.journalResearchArea | Physiology | - |
dc.relation.journalWebOfScienceCategory | Cell Biology | - |
dc.relation.journalWebOfScienceCategory | Physiology | - |
dc.subject.keywordPlus | PROSTATE-CANCER CELLS | - |
dc.subject.keywordPlus | LOOP-HELIX PROTEINS | - |
dc.subject.keywordPlus | NF-KAPPA-B | - |
dc.subject.keywordPlus | BREAST-CANCER | - |
dc.subject.keywordPlus | BETA-CATENIN | - |
dc.subject.keywordPlus | HEPATOCELLULAR-CARCINOMA | - |
dc.subject.keywordPlus | SIGNALING PATHWAY | - |
dc.subject.keywordPlus | INDUCED APOPTOSIS | - |
dc.subject.keywordPlus | GENE-EXPRESSION | - |
dc.subject.keywordPlus | ACTIVATION | - |
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