DHS-21, a dicarbonyl/L-xylulose reductase (DCXR) ortholog, regulates longevity and reproduction in Caenorhabditis elegans
DC Field | Value | Language |
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dc.contributor.author | Son, Le Tho | - |
dc.contributor.author | Ko, Kyung-Min | - |
dc.contributor.author | Cho, Jeong Hoon | - |
dc.contributor.author | Singaravelu, Gunasekaran | - |
dc.contributor.author | Chatterjee, Indrani | - |
dc.contributor.author | Choi, Tae-Woo | - |
dc.contributor.author | Song, Hyun-Ok | - |
dc.contributor.author | Yu, Jae-Ran | - |
dc.contributor.author | Park, Byung-Jae | - |
dc.contributor.author | Lee, Sun-Kyung | - |
dc.contributor.author | Ahnn, Joohong | - |
dc.date.accessioned | 2022-07-16T20:50:17Z | - |
dc.date.available | 2022-07-16T20:50:17Z | - |
dc.date.created | 2021-05-12 | - |
dc.date.issued | 2011-05 | - |
dc.identifier.issn | 0014-5793 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/hanyang/handle/2021.sw.hanyang/168568 | - |
dc.description.abstract | Dicarbonyl/L-xylulose reductase (DCXR) converts L-xylulose into xylitol, and reduces various a-dicarbonyl compounds, thus performing a dual role in carbohydrate metabolism and detoxification. In this study, we identified DHS-21 as the only DCXR ortholog in Caenorhabditis elegans. The dhs-21 gene is expressed in various tissues including the intestine, gonadal sheath cells, uterine seam (utse) cells, the spermathecal-uterus (sp-ut) valve and on the plasma membrane of spermatids. Recombinant DHS-21 was shown to convert L-xylulose to xylitol using NADPH as a cofactor. Dhs-21 null mutants of C. elegans show defects in longevity, reproduction and egg-laying. Knock-down of daf-16 and elt-2 transcription factors affected dhs-21 expression. These results suggest that DHS-21 is a bona fide DCXR of C. elegans, essential for normal life span and reproduction. | - |
dc.language | 영어 | - |
dc.language.iso | en | - |
dc.publisher | ELSEVIER SCIENCE BV | - |
dc.title | DHS-21, a dicarbonyl/L-xylulose reductase (DCXR) ortholog, regulates longevity and reproduction in Caenorhabditis elegans | - |
dc.type | Article | - |
dc.contributor.affiliatedAuthor | Ahnn, Joohong | - |
dc.identifier.doi | 10.1016/j.febslet.2011.03.062 | - |
dc.identifier.scopusid | 2-s2.0-79955597237 | - |
dc.identifier.wosid | 000290248300010 | - |
dc.identifier.bibliographicCitation | FEBS LETTERS, v.585, no.9, pp.1310 - 1316 | - |
dc.relation.isPartOf | FEBS LETTERS | - |
dc.citation.title | FEBS LETTERS | - |
dc.citation.volume | 585 | - |
dc.citation.number | 9 | - |
dc.citation.startPage | 1310 | - |
dc.citation.endPage | 1316 | - |
dc.type.rims | ART | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
dc.description.isOpenAccess | N | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Biochemistry & Molecular Biology | - |
dc.relation.journalResearchArea | Biophysics | - |
dc.relation.journalResearchArea | Cell Biology | - |
dc.relation.journalWebOfScienceCategory | Biochemistry & Molecular Biology | - |
dc.relation.journalWebOfScienceCategory | Biophysics | - |
dc.relation.journalWebOfScienceCategory | Cell Biology | - |
dc.subject.keywordPlus | C-ELEGANS | - |
dc.subject.keywordPlus | LIFE-SPAN | - |
dc.subject.keywordPlus | OVULATION | - |
dc.subject.keywordPlus | LOCALIZATION | - |
dc.subject.keywordPlus | EXPRESSION | - |
dc.subject.keywordPlus | KIDNEY | - |
dc.subject.keywordPlus | YEAST | - |
dc.subject.keywordAuthor | dhs-21 | - |
dc.subject.keywordAuthor | L-Xylulose reductase | - |
dc.subject.keywordAuthor | Longevity | - |
dc.subject.keywordAuthor | Egg-laying | - |
dc.subject.keywordAuthor | Gene expression | - |
dc.identifier.url | https://febs.onlinelibrary.wiley.com/doi/full/10.1016/j.febslet.2011.03.062 | - |
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