Stability of commonly used antibiotics solutions in the accufuser® elastometric infusion device under recommended storage and used conditions
DC Field | Value | Language |
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dc.contributor.author | Lee, Ga-Young | - |
dc.contributor.author | Kim, Min-Jeong | - |
dc.contributor.author | Kang, Mina | - |
dc.contributor.author | Park, Yoo-Sin | - |
dc.contributor.author | Kim, Shin-Hee | - |
dc.contributor.author | Kim, Sang-Yeon | - |
dc.contributor.author | Kang, Ju-Seop | - |
dc.date.accessioned | 2022-07-16T21:01:46Z | - |
dc.date.available | 2022-07-16T21:01:46Z | - |
dc.date.created | 2021-05-13 | - |
dc.date.issued | 2011-04 | - |
dc.identifier.issn | 1876-3960 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/hanyang/handle/2021.sw.hanyang/168707 | - |
dc.description.abstract | Objectives: The stability of two kinds of solution of penicillin G potassium [PEN-K, 10K U/mL in 5% dextrose water, D5W and 50K U/mL in 0.9% sodium chloride in water, NS) into the intravenous infusion device, Accufuser®, storage were evaluated at controlled temperature (CT, 4±2°C and RT, 25±2°C) during 6 weeks. Methods: Studies were performed using both NS (PEN-K 50K U/mL) and D5W (PEN-K 10K U/mL) injectable solutions. The resulting solutions were transferred to Accufuser® infusion device for storage at CT or RT. Effects of period of storage (from 0 to 6 weeks) and temperature (CT and RT) on the physical appearance and concentrations of PEN-K were determined by visual clarity, pH and antibiotic concentrations by measurement with stability-indicating high-performance liquid chromatography (HPLC) method. Results: In NS (50 K U/mL) and D5W (10K U/mL) solutions, concentrations of PEN-K were slightly change and remained 94.18 and 83.42% at CT after 1 week, respectively. Otherwise, these were rapidly decreased with time and reached to 74.65 and 75.59% in NS (50K U/mL) and D5W (10K U/mL) solutions at RT after 48 h, respectively. Moderate decrement of pH was observed in cold storage and it was shown no significant changes at 6 weeks in the RT conditions. In CT, no significant changes in physical appearance or color of the solutions were observed during the study. Conclusion: Two kinds of PEN-K D5W(10K U/mL) and NS(50K U/mL) solution were shown different chemical stability with time in Accufuser® infusion device without any significant physical change and retained about 70% of initial concentration after 48 h in RT and 80 % after 2 weeks in CT, respectively. We suggested that PEN-K solutions of 50K U/mL NS and 10K U/mL D5W in an Accufuser® infusion device should be preferentially applicable only in CT for 48 h in clinical situations. | - |
dc.language | 영어 | - |
dc.language.iso | en | - |
dc.publisher | Bentham Open | - |
dc.title | Stability of commonly used antibiotics solutions in the accufuser® elastometric infusion device under recommended storage and used conditions | - |
dc.type | Article | - |
dc.contributor.affiliatedAuthor | Kang, Ju-Seop | - |
dc.identifier.doi | 10.2174/1876396001104010125 | - |
dc.identifier.scopusid | 2-s2.0-79958106983 | - |
dc.identifier.bibliographicCitation | Open Nutraceuticals Journal, v.4, pp.125 - 129 | - |
dc.relation.isPartOf | Open Nutraceuticals Journal | - |
dc.citation.title | Open Nutraceuticals Journal | - |
dc.citation.volume | 4 | - |
dc.citation.startPage | 125 | - |
dc.citation.endPage | 129 | - |
dc.type.rims | ART | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
dc.description.isOpenAccess | Y | - |
dc.description.journalRegisteredClass | scopus | - |
dc.subject.keywordPlus | glucose | - |
dc.subject.keywordPlus | infusion fluid | - |
dc.subject.keywordPlus | penicillin G potassium | - |
dc.subject.keywordPlus | sodium chloride | - |
dc.subject.keywordPlus | glucose | - |
dc.subject.keywordPlus | sodium chloride | - |
dc.subject.keywordPlus | article | - |
dc.subject.keywordPlus | cold | - |
dc.subject.keywordPlus | color | - |
dc.subject.keywordPlus | controlled study | - |
dc.subject.keywordPlus | drug concentration | - |
dc.subject.keywordPlus | drug mixture | - |
dc.subject.keywordPlus | drug stability | - |
dc.subject.keywordPlus | drug structure | - |
dc.subject.keywordPlus | high performance liquid chromatography | - |
dc.subject.keywordPlus | infusion system | - |
dc.subject.keywordPlus | pH | - |
dc.subject.keywordPlus | priority journal | - |
dc.subject.keywordPlus | room temperature | - |
dc.subject.keywordPlus | storage temperature | - |
dc.subject.keywordPlus | accuracy | - |
dc.subject.keywordPlus | biosafety | - |
dc.subject.keywordPlus | drug dosage form comparison | - |
dc.subject.keywordPlus | drug solution | - |
dc.subject.keywordPlus | drug storage | - |
dc.subject.keywordPlus | physical appearance | - |
dc.subject.keywordPlus | physical parameters | - |
dc.subject.keywordAuthor | Accufuser® | - |
dc.subject.keywordAuthor | Infusion device | - |
dc.subject.keywordAuthor | Penicillin G potassium | - |
dc.subject.keywordAuthor | Stability | - |
dc.identifier.url | https://benthamopen.com/ABSTRACT/TONUTRAJ-4-125 | - |
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