Clinicopathologic significance of GLUT1 expression and its correlation with Apaf-1 in colorectal adenocarcinomas
DC Field | Value | Language |
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dc.contributor.author | Jun, Young Jin | - |
dc.contributor.author | Jang, Se Min | - |
dc.contributor.author | Han, Hu Lin | - |
dc.contributor.author | Lee, Kang Hong | - |
dc.contributor.author | Jang, Ki-Seok | - |
dc.contributor.author | Paik, Seung Sam | - |
dc.date.accessioned | 2022-07-16T21:16:27Z | - |
dc.date.available | 2022-07-16T21:16:27Z | - |
dc.date.created | 2021-05-12 | - |
dc.date.issued | 2011-04 | - |
dc.identifier.issn | 1007-9327 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/hanyang/handle/2021.sw.hanyang/168755 | - |
dc.description.abstract | AIM: To investigate the role of glucose transporter 1 (GLUT1) expression in colorectal carcinogenesis and evaluate the correlation with clinicopathological parameters and apoptosis-activating factor-1 (Apaf-1) expression in colorectal adenocarcinomas. METHODS: We used tissue microarrays consisting of 26 normal mucosa, 50 adenomas, 515 adenocarcinomas, and 127 metastatic lesions. Medical records were reviewed and clinicopathological analysis was performed. RESULTS: GLUT1 expression was absent in normal mucosa and low or moderately apparent in 19 cases (38.0%) of 50 adenomas. However, GLUT1 expression was detected in 423 (82.1%) of 515 adenocarcinomas and in 96 (75.6%) of 127 metastatic lesions. GLUT1 expression was significantly correlated with female gender (P = 0.009), non-mucinous tumor type (P = 0.045), poorer differentiation (P = 0.001), lymph node metastasis (P < 0.001), higher AJCC and Dukes stage (P < 0.001 and P < 0.001, respectively). There was a significant inverse correlation between GLUT1 expression and Apaf-1 expression (P = 0.001). In univariate survival analysis, patients with GLUT1 expression demonstrated poor overall survival and disease-free survival (P = 0.047 and P = 0.021, respectively, log-rank test). CONCLUSION: GLUT1 expression was frequently increased in adenocarcinomas and metastatic lesions. GLUT1 expression was significantly correlated with poorer clinicopathologic phenotypes and survival of patients with colorectal adenocarcinomas. | - |
dc.language | 영어 | - |
dc.language.iso | en | - |
dc.publisher | BAISHIDENG PUBLISHING GROUP INC | - |
dc.title | Clinicopathologic significance of GLUT1 expression and its correlation with Apaf-1 in colorectal adenocarcinomas | - |
dc.type | Article | - |
dc.contributor.affiliatedAuthor | Lee, Kang Hong | - |
dc.contributor.affiliatedAuthor | Jang, Ki-Seok | - |
dc.contributor.affiliatedAuthor | Paik, Seung Sam | - |
dc.identifier.doi | 10.3748/wjg.v17.i14.1866 | - |
dc.identifier.scopusid | 2-s2.0-79955935686 | - |
dc.identifier.wosid | 000290124300012 | - |
dc.identifier.bibliographicCitation | WORLD JOURNAL OF GASTROENTEROLOGY, v.17, no.14, pp.1866 - 1873 | - |
dc.relation.isPartOf | WORLD JOURNAL OF GASTROENTEROLOGY | - |
dc.citation.title | WORLD JOURNAL OF GASTROENTEROLOGY | - |
dc.citation.volume | 17 | - |
dc.citation.number | 14 | - |
dc.citation.startPage | 1866 | - |
dc.citation.endPage | 1873 | - |
dc.type.rims | ART | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
dc.description.isOpenAccess | N | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Gastroenterology & Hepatology | - |
dc.relation.journalWebOfScienceCategory | Gastroenterology & Hepatology | - |
dc.subject.keywordPlus | HYPOXIA-INDUCED APOPTOSIS | - |
dc.subject.keywordPlus | SMOOTH-MUSCLE-CELLS | - |
dc.subject.keywordPlus | GLUCOSE-TRANSPORTER | - |
dc.subject.keywordPlus | GROWTH-FACTORS | - |
dc.subject.keywordPlus | CANCER | - |
dc.subject.keywordPlus | TUMOR | - |
dc.subject.keywordPlus | CARCINOMA | - |
dc.subject.keywordPlus | OVEREXPRESSION | - |
dc.subject.keywordPlus | METABOLISM | - |
dc.subject.keywordPlus | PROGNOSIS | - |
dc.subject.keywordAuthor | Adenocarcinoma | - |
dc.subject.keywordAuthor | Colorectum | - |
dc.subject.keywordAuthor | Glucose transporter-1 | - |
dc.subject.keywordAuthor | Apoptosis-activating factor-1 | - |
dc.subject.keywordAuthor | Prognosis | - |
dc.subject.keywordAuthor | Survival | - |
dc.identifier.url | https://www.wjgnet.com/1007-9327/full/v17/i14/1866.htm | - |
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