Brief review of the role of glycogen synthase kinase-3β in amyotrophic lateral sclerosis
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Koh, Seong-Ho | - |
dc.contributor.author | Baek, Wonki | - |
dc.contributor.author | Kim, Seung H | - |
dc.date.accessioned | 2022-07-16T21:38:12Z | - |
dc.date.available | 2022-07-16T21:38:12Z | - |
dc.date.created | 2021-05-11 | - |
dc.date.issued | 2011-03 | - |
dc.identifier.issn | 2090-1852 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/hanyang/handle/2021.sw.hanyang/168966 | - |
dc.description.abstract | Glycogen synthase kinase-3β (GSK-3β) is known to affect a diverse range of biological functions controlling gene expression, cellular architecture, and apoptosis. GSK-3β has recently been identified as one of the important pathogenicmechanisms inmotor neuronal death related to amyotrophic lateral sclerosis (ALS). Therefore, the development of methods to control GSK-3β could be helpful in postponing the symptom progression of ALS. Here we discuss the known roles of GSK-3β in motor neuronal cell death in ALS and the possibility of employing GSK-3β modulators as a new therapeutic strategy. | - |
dc.language | 영어 | - |
dc.language.iso | en | - |
dc.publisher | Hindawi Publishing Corporation | - |
dc.title | Brief review of the role of glycogen synthase kinase-3β in amyotrophic lateral sclerosis | - |
dc.type | Article | - |
dc.contributor.affiliatedAuthor | Kim, Seung H | - |
dc.identifier.doi | 10.1155/2011/205761 | - |
dc.identifier.scopusid | 2-s2.0-80051718959 | - |
dc.identifier.bibliographicCitation | Neurology Research International, v.2011, pp.1 - 5 | - |
dc.relation.isPartOf | Neurology Research International | - |
dc.citation.title | Neurology Research International | - |
dc.citation.volume | 2011 | - |
dc.citation.startPage | 1 | - |
dc.citation.endPage | 5 | - |
dc.type.rims | ART | - |
dc.type.docType | Review | - |
dc.description.journalClass | 1 | - |
dc.description.isOpenAccess | Y | - |
dc.description.journalRegisteredClass | scopus | - |
dc.identifier.url | https://www.hindawi.com/journals/nri/2011/205761/ | - |
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