소동물 [F-18]FDG 양전자단층촬영 기법을 이용한 청각신경에서의 소리크기에 대한 적응효과 연구
DC Field | Value | Language |
---|---|---|
dc.contributor.author | 장동표 | - |
dc.date.accessioned | 2022-07-16T21:40:16Z | - |
dc.date.available | 2022-07-16T21:40:16Z | - |
dc.date.created | 2021-05-13 | - |
dc.date.issued | 2011-02 | - |
dc.identifier.issn | 1229-0807 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/hanyang/handle/2021.sw.hanyang/168995 | - |
dc.description.abstract | Although sound intensity is considered as one of important factors in auditory processing, its neural mechanism in auditory neurons with limited dynamic range of firing rates is still unclear. In this study, we examined the effect of sound intensity adaptation on the change of glucose metabolism in a rat brain using [F-18] micro positron emission tomography (PET) neuroimaging technique. In the experiment, broadband white noise sound was given for 30 minutes after the [F-18]FDG injection in order to explore the functional adaptation of rat brain into the sound intensity levels. Nine rats were scanned with four different sound intensity levels: 40 dB, 60 dB, 80 dB, 100 dB sound pressure level (SPL) for four weeks. When glucose uptake during the adaptation of a high intensity sound level (100 dB SPL) was compared with that during adaptation to a low intensity level (40 dB SPL) in the experiment, the former induced a greater uptake at bilateral cochlear nucleus, superior olivary complexes and inferior colliculi in the auditory pathway. Expectedly, the metabolic activity in those areas linearly increased as the sound intensity level increased. In contrast, significant decrease interestingly occurred in the bilateral auditory cortices: The activities of auditory cortex proportionally decreased with higher sound intensities. It may reflect that the auditory cortex actively down-regulates neural activities when the sound gets louder. | - |
dc.language | 한국어 | - |
dc.language.iso | ko | - |
dc.publisher | 대한의용생체공학회 | - |
dc.title | 소동물 [F-18]FDG 양전자단층촬영 기법을 이용한 청각신경에서의 소리크기에 대한 적응효과 연구 | - |
dc.title.alternative | The Effect of Adaptation to Sound Intensity on the Neural Metabolism in Auditory Pathway: Small Animal PET Study | - |
dc.type | Article | - |
dc.contributor.affiliatedAuthor | 장동표 | - |
dc.identifier.doi | 10.9718/JBER.2011.32.1.055 | - |
dc.identifier.bibliographicCitation | 의공학회지, v.32, no.1, pp.55 - 60 | - |
dc.relation.isPartOf | 의공학회지 | - |
dc.citation.title | 의공학회지 | - |
dc.citation.volume | 32 | - |
dc.citation.number | 1 | - |
dc.citation.startPage | 55 | - |
dc.citation.endPage | 60 | - |
dc.type.rims | ART | - |
dc.type.docType | 정기학술지(Article(Perspective Article포함)) | - |
dc.identifier.kciid | ART001537923 | - |
dc.description.journalClass | 2 | - |
dc.description.isOpenAccess | N | - |
dc.description.journalRegisteredClass | kci | - |
dc.subject.keywordAuthor | Sound Intensity | - |
dc.subject.keywordAuthor | Auditory processing | - |
dc.subject.keywordAuthor | [F-18]FDG | - |
dc.subject.keywordAuthor | small animal PET | - |
Items in ScholarWorks are protected by copyright, with all rights reserved, unless otherwise indicated.
222, Wangsimni-ro, Seongdong-gu, Seoul, 04763, Korea+82-2-2220-1365
COPYRIGHT © 2021 HANYANG UNIVERSITY.
Certain data included herein are derived from the © Web of Science of Clarivate Analytics. All rights reserved.
You may not copy or re-distribute this material in whole or in part without the prior written consent of Clarivate Analytics.