Effects of demographic factors on cortical thickness in Alzheimer's disease
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Seo, Sang Won | - |
dc.contributor.author | Im, Kiho | - |
dc.contributor.author | Lee, Jong-Min | - |
dc.contributor.author | Kim, Sung Tae | - |
dc.contributor.author | Ahn, Hyun Jung | - |
dc.contributor.author | Go, Seok Min | - |
dc.contributor.author | Kim, Sook-Hui | - |
dc.contributor.author | Na, Duk L. | - |
dc.date.accessioned | 2022-07-16T21:48:37Z | - |
dc.date.available | 2022-07-16T21:48:37Z | - |
dc.date.created | 2021-05-12 | - |
dc.date.issued | 2011-02 | - |
dc.identifier.issn | 0197-4580 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/hanyang/handle/2021.sw.hanyang/169087 | - |
dc.description.abstract | The aim of this study was to investigate the effect of demographic factors (age of onset, sex and years of education) on the distribution of cortical thickness in a large sample of patients with Alzheimer's disease (AD). The study participants consisted of 193 AD patients and 142 controls with no cognitive impairment (NCI) that were measured with cortical thickness across the entire brain. The effects of demographic factors on cortical thickness were analyzed by applying linear regression after controlling confounding factors. Older individuals in NCI group showed more cortical thinning in frontal, temporal association cortices and insula than younger participants. Early onset AD was associated with cortical thinning in the parietal lobe, whereas late onset AD was associated with cortical thinning in the medial temporal region. The NCI group demonstrated sex-related differences in cortical thickness, although those differences were not present in the AD group. While the education effect was absent in NCI individuals, high levels of education in the AD group correlated with cortical thinning in the frontal and temporoparietal association cortices. Our results show that AD with earlier onset and higher education had suffered more pronounced cortical atrophy in specific parts of the brain than their counterparts, which may be related to cognitive reserve theory. | - |
dc.language | 영어 | - |
dc.language.iso | en | - |
dc.publisher | ELSEVIER SCIENCE INC | - |
dc.title | Effects of demographic factors on cortical thickness in Alzheimer's disease | - |
dc.type | Article | - |
dc.contributor.affiliatedAuthor | Lee, Jong-Min | - |
dc.identifier.doi | 10.1016/j.neurobiolaging.2009.02.004 | - |
dc.identifier.scopusid | 2-s2.0-78649854850 | - |
dc.identifier.wosid | 000285219600002 | - |
dc.identifier.bibliographicCitation | Neurobiology of Aging, v.32, no.2, pp.200 - 209 | - |
dc.relation.isPartOf | Neurobiology of Aging | - |
dc.citation.title | Neurobiology of Aging | - |
dc.citation.volume | 32 | - |
dc.citation.number | 2 | - |
dc.citation.startPage | 200 | - |
dc.citation.endPage | 209 | - |
dc.type.rims | ART | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
dc.description.isOpenAccess | N | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Geriatrics & Gerontology | - |
dc.relation.journalResearchArea | Neurosciences & Neurology | - |
dc.relation.journalWebOfScienceCategory | Geriatrics & Gerontology | - |
dc.relation.journalWebOfScienceCategory | Neurosciences | - |
dc.subject.keywordPlus | MILD COGNITIVE IMPAIRMENT | - |
dc.subject.keywordPlus | CEREBRAL-BLOOD-FLOW | - |
dc.subject.keywordPlus | LATE-ONSET TYPES | - |
dc.subject.keywordPlus | RESERVE-HYPOTHESIS | - |
dc.subject.keywordPlus | SEX-DIFFERENCES | - |
dc.subject.keywordPlus | BRAIN RESERVE | - |
dc.subject.keywordPlus | HEALTHY-YOUNG | - |
dc.subject.keywordPlus | DEMENTIA | - |
dc.subject.keywordPlus | EDUCATION | - |
dc.subject.keywordPlus | GENDER | - |
dc.subject.keywordAuthor | Alzheimer&apos | - |
dc.subject.keywordAuthor | s disease | - |
dc.subject.keywordAuthor | Age of onset | - |
dc.subject.keywordAuthor | Sex | - |
dc.subject.keywordAuthor | Years of education | - |
dc.subject.keywordAuthor | Cortical thickness | - |
dc.subject.keywordAuthor | Cognitive reserve | - |
dc.identifier.url | https://www.sciencedirect.com/science/article/pii/S0197458009000372?via%3Dihub | - |
Items in ScholarWorks are protected by copyright, with all rights reserved, unless otherwise indicated.
222, Wangsimni-ro, Seongdong-gu, Seoul, 04763, Korea+82-2-2220-1365
COPYRIGHT © 2021 HANYANG UNIVERSITY.
Certain data included herein are derived from the © Web of Science of Clarivate Analytics. All rights reserved.
You may not copy or re-distribute this material in whole or in part without the prior written consent of Clarivate Analytics.