Preparation of Dexamethasone-Based Cationic Liposome and Its Application to Gene Delivery In Vitro
DC Field | Value | Language |
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dc.contributor.author | Kim, Tae-Hun | - |
dc.contributor.author | Yu, Gwang Sig | - |
dc.contributor.author | Choi, Hye | - |
dc.contributor.author | Shim, Young Jung | - |
dc.contributor.author | Lee, Minhyung | - |
dc.contributor.author | Choi, Joon Sig | - |
dc.date.accessioned | 2022-07-16T21:49:01Z | - |
dc.date.available | 2022-07-16T21:49:01Z | - |
dc.date.created | 2021-05-12 | - |
dc.date.issued | 2011-02 | - |
dc.identifier.issn | 1533-4880 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/hanyang/handle/2021.sw.hanyang/169091 | - |
dc.description.abstract | In this study, dexamethasone was conjugated to PAMAM dendrimer (generation 0) and its gene transfection efficiency was investigated. To make a liposomal solution for gene delivery, DOPE was used as a fusogenic helper lipid. In gel retardation assay, PAMAM-dexamethasone conjugate (PAM-Dex)/DOPE liposome/DNA complex was completely retarded at 8:1 N/P (nitrogen/phosphate) ratio. The physicochemical characteristics are studied by measuring the average size distribution and zeta-potential values of the complexes. In vitro transfection assay showed that the PAM-Dex/DOPE liposome/DNA complex displayed higher gene delivery efficiency compared to PAMAM/DNA complex. In addition, PAM-Dex/DOPE liposome showed the lowest toxicity compared to PAMAM, PEI 25 kD and Lipofectamine. These results indicate that PAM-Dex/DOPE liposome has a potential to be used as an efficient gene carrier for gene therapy. | - |
dc.language | 영어 | - |
dc.language.iso | en | - |
dc.publisher | AMER SCIENTIFIC PUBLISHERS | - |
dc.title | Preparation of Dexamethasone-Based Cationic Liposome and Its Application to Gene Delivery In Vitro | - |
dc.type | Article | - |
dc.contributor.affiliatedAuthor | Lee, Minhyung | - |
dc.identifier.doi | 10.1166/jnn.2011.3407 | - |
dc.identifier.scopusid | 2-s2.0-79954995152 | - |
dc.identifier.wosid | 000287167900178 | - |
dc.identifier.bibliographicCitation | JOURNAL OF NANOSCIENCE AND NANOTECHNOLOGY, v.11, no.2, pp.1799 - 1802 | - |
dc.relation.isPartOf | JOURNAL OF NANOSCIENCE AND NANOTECHNOLOGY | - |
dc.citation.title | JOURNAL OF NANOSCIENCE AND NANOTECHNOLOGY | - |
dc.citation.volume | 11 | - |
dc.citation.number | 2 | - |
dc.citation.startPage | 1799 | - |
dc.citation.endPage | 1802 | - |
dc.type.rims | ART | - |
dc.type.docType | Article; Proceedings Paper | - |
dc.description.journalClass | 1 | - |
dc.description.isOpenAccess | N | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Chemistry | - |
dc.relation.journalResearchArea | Science & Technology - Other Topics | - |
dc.relation.journalResearchArea | Materials Science | - |
dc.relation.journalResearchArea | Physics | - |
dc.relation.journalWebOfScienceCategory | Chemistry, Multidisciplinary | - |
dc.relation.journalWebOfScienceCategory | Nanoscience & Nanotechnology | - |
dc.relation.journalWebOfScienceCategory | Materials Science, Multidisciplinary | - |
dc.relation.journalWebOfScienceCategory | Physics, Applied | - |
dc.relation.journalWebOfScienceCategory | Physics, Condensed Matter | - |
dc.subject.keywordPlus | TRANSFECTION EFFICIENCY | - |
dc.subject.keywordPlus | POLYETHYLENIMINE | - |
dc.subject.keywordPlus | DENDRIMER | - |
dc.subject.keywordPlus | NUCLEUS | - |
dc.subject.keywordPlus | CARRIER | - |
dc.subject.keywordAuthor | Dendrimer | - |
dc.subject.keywordAuthor | Dexamethasone | - |
dc.subject.keywordAuthor | Cationic Liposome | - |
dc.subject.keywordAuthor | Gene Transfection | - |
dc.identifier.url | https://www.ingentaconnect.com/content/asp/jnn/2011/00000011/00000002/art00178;jsessionid=1hl0bg3y8x77i.x-ic-live-01 | - |
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