Genetic Studies of Ankylosing Spondylitis in Koreans Confirm Associations with ERAP1 and 2p15 Reported in White Patients
DC Field | Value | Language |
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dc.contributor.author | Bang, So-Young | - |
dc.contributor.author | Kim, Tae-Hwan | - |
dc.contributor.author | Lee, Bitnara | - |
dc.contributor.author | Kwon, Eunji | - |
dc.contributor.author | Choi, Sang Hyun | - |
dc.contributor.author | Lee, Ki Soo | - |
dc.contributor.author | Shim, Seung Cheol | - |
dc.contributor.author | Pope, Angela | - |
dc.contributor.author | Rahman, Proton | - |
dc.contributor.author | Reveille, John D. | - |
dc.contributor.author | Inman, Robert D. | - |
dc.date.accessioned | 2022-07-16T22:09:49Z | - |
dc.date.available | 2022-07-16T22:09:49Z | - |
dc.date.created | 2021-05-11 | - |
dc.date.issued | 2011-02 | - |
dc.identifier.issn | 0315-162X | - |
dc.identifier.uri | https://scholarworks.bwise.kr/hanyang/handle/2021.sw.hanyang/169156 | - |
dc.description.abstract | Objective. Investigators from the Australo-Anglo-American Spondyloarthritis Consortium have reported additional genes associated with ankylosing spondylitis (AS) susceptibility including IL1R2, ANTXR2, and gene deserts at 2p15 and 21q22. We evaluated these new candidate genes in a large cohort of Korean patients with AS. Methods. A group of 1164 patients with AS and 752 healthy controls were enrolled for our study. Eight single-nucleotide polymorphisms (SNP) were analyzed to define genetic association with AS by MassARRAY system. Results. Significant positive associations of AS with endoplasmic reticulum aminopeptidase 1 SNP, rs27037 (p = 1.31 x 10(-4)), and rs27434 (p = 4.59 x 10(-6)), were observed. The rs10865331 of gene desert at 2p15 also showed a significant association with AS (p = 4.63 x 10(-5)). Conclusion. This is the first confirmation in a nonwhite population that genetic polymorphisms of rs27037, rs27434, and rs10865331 are associated with AS, implicating common pathogenetic mechanisms in Korean and white patients with AS. (First Release Nov 1 2010; J Rheumatol 2011; 38:322-4; doi:10.3899/jrheum.100652) | - |
dc.language | 영어 | - |
dc.language.iso | en | - |
dc.publisher | J RHEUMATOL PUBL CO | - |
dc.title | Genetic Studies of Ankylosing Spondylitis in Koreans Confirm Associations with ERAP1 and 2p15 Reported in White Patients | - |
dc.type | Article | - |
dc.contributor.affiliatedAuthor | Bang, So-Young | - |
dc.contributor.affiliatedAuthor | Kim, Tae-Hwan | - |
dc.identifier.doi | 10.3899/jrheum.100652 | - |
dc.identifier.scopusid | 2-s2.0-79551717945 | - |
dc.identifier.wosid | 000287173000022 | - |
dc.identifier.bibliographicCitation | JOURNAL OF RHEUMATOLOGY, v.38, no.2, pp.322 - 324 | - |
dc.relation.isPartOf | JOURNAL OF RHEUMATOLOGY | - |
dc.citation.title | JOURNAL OF RHEUMATOLOGY | - |
dc.citation.volume | 38 | - |
dc.citation.number | 2 | - |
dc.citation.startPage | 322 | - |
dc.citation.endPage | 324 | - |
dc.type.rims | ART | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
dc.description.isOpenAccess | N | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Rheumatology | - |
dc.relation.journalWebOfScienceCategory | Rheumatology | - |
dc.subject.keywordPlus | GENOME-WIDE ASSOCIATION | - |
dc.subject.keywordPlus | POLYMORPHISMS | - |
dc.subject.keywordPlus | PATHOGENESIS | - |
dc.subject.keywordPlus | VARIANTS | - |
dc.subject.keywordAuthor | ANKYLOSING SPONDYLITIS | - |
dc.subject.keywordAuthor | ERAP1 | - |
dc.subject.keywordAuthor | 2p15 | - |
dc.subject.keywordAuthor | KOREA | - |
dc.subject.keywordAuthor | SINGLE-NUCLEOTIDE POLYMORPHISM | - |
dc.identifier.url | https://www.jrheum.org/content/38/2/322 | - |
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