Dysadherin can enhance tumorigenesis by conferring properties of stem-like cells to hepatocellular carcinoma cells
DC Field | Value | Language |
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dc.contributor.author | Park, Jeong-Ran | - |
dc.contributor.author | Kim, Ran-Ju | - |
dc.contributor.author | Lee, Yoo-Kyung | - |
dc.contributor.author | Kim, Soo-Rim | - |
dc.contributor.author | Roh, Kyung-Jin | - |
dc.contributor.author | Oh, Seung Hyun | - |
dc.contributor.author | Kong, Gu | - |
dc.contributor.author | Kang, Kyung-Sun | - |
dc.contributor.author | Nam, Jeong-Seok | - |
dc.date.accessioned | 2022-07-16T22:19:32Z | - |
dc.date.available | 2022-07-16T22:19:32Z | - |
dc.date.created | 2021-05-12 | - |
dc.date.issued | 2011-01 | - |
dc.identifier.issn | 0168-8278 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/hanyang/handle/2021.sw.hanyang/169257 | - |
dc.description.abstract | Background & Aims: Hepatocellular carcinoma (HCC) is associated with a high potential for metastasis and disease recurrence, even after surgical resection. The cancer stem cell (CSC) hypothesis proposes that CSCs are responsible for chemo-resistance, recurrence, and metastasis. Dysadherin is a prognostic indicator of metastasis and poor survival in many different cancer types. In this study, we investigated the possible link between dysadherin and CSC in HCC. Methods: We analyzed the functional implications of dysadherin on cancer sternness by modification of the dysadherin gene in HCC cell lines. Results: The transfection of dysadherin cDNA into the liver cancer cell line PLC/PRF/5 enhanced the properties of CSCs, including anti-apoptosis, their sphere-forming ability, side population phenotype, and tumor initiation ability in vivo. Furthermore, knockdown of dysadherin in the liver cancer cell line SK-Hep1 suppressed its stem cell-like properties. Conclusions: These results show that dysadherin give rise to properties of CSC in HCC. Therefore, these findings suggest that dysadherin may be a potential molecular prognostic marker of HCC and may aid in the development of more effective therapies. | - |
dc.language | 영어 | - |
dc.language.iso | en | - |
dc.publisher | ELSEVIER | - |
dc.title | Dysadherin can enhance tumorigenesis by conferring properties of stem-like cells to hepatocellular carcinoma cells | - |
dc.type | Article | - |
dc.contributor.affiliatedAuthor | Kong, Gu | - |
dc.identifier.doi | 10.1016/j.jhep.2010.06.026 | - |
dc.identifier.scopusid | 2-s2.0-78649636884 | - |
dc.identifier.wosid | 000286124200020 | - |
dc.identifier.bibliographicCitation | JOURNAL OF HEPATOLOGY, v.54, no.1, pp.122 - 131 | - |
dc.relation.isPartOf | JOURNAL OF HEPATOLOGY | - |
dc.citation.title | JOURNAL OF HEPATOLOGY | - |
dc.citation.volume | 54 | - |
dc.citation.number | 1 | - |
dc.citation.startPage | 122 | - |
dc.citation.endPage | 131 | - |
dc.type.rims | ART | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
dc.description.isOpenAccess | N | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Gastroenterology & Hepatology | - |
dc.relation.journalWebOfScienceCategory | Gastroenterology & Hepatology | - |
dc.subject.keywordPlus | EPITHELIAL-MESENCHYMAL TRANSITION | - |
dc.subject.keywordPlus | COLORECTAL-CANCER | - |
dc.subject.keywordPlus | SIDE POPULATION | - |
dc.subject.keywordPlus | E-CADHERIN | - |
dc.subject.keywordPlus | EXPRESSION | - |
dc.subject.keywordPlus | TUMORS | - |
dc.subject.keywordPlus | GLYCOPROTEIN | - |
dc.subject.keywordPlus | RESISTANCE | - |
dc.subject.keywordPlus | PROMOTES | - |
dc.subject.keywordAuthor | Dysadherin | - |
dc.subject.keywordAuthor | Hepatocellular carcinoma | - |
dc.subject.keywordAuthor | Cancer stem cell | - |
dc.subject.keywordAuthor | Side population | - |
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