Akt isoform-specific inhibition of MDA-MB-231 cell proliferation
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Yang, Wonseok | - |
dc.contributor.author | Ju, Ji-hyun | - |
dc.contributor.author | Lee, Kyung-min | - |
dc.contributor.author | Shin, Incheol | - |
dc.date.accessioned | 2022-07-16T22:21:05Z | - |
dc.date.available | 2022-07-16T22:21:05Z | - |
dc.date.created | 2021-05-12 | - |
dc.date.issued | 2011-01 | - |
dc.identifier.issn | 0898-6568 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/hanyang/handle/2021.sw.hanyang/169271 | - |
dc.description.abstract | To dissect the isoform-specific roles of Akt in breast cancer cells, constitutively active Akt isoforms were introduced into MDA-MB-231 cells. Both Akt1 and Akt2 efficiently inhibited the growth of MDA-MB-231 cells. Overexpression of Akt1 down-regulated ERK activity inhibiting Ser 259 phosphorylation of c-Raf and subsequent downstream signaling. Akt2 overexpression up-regulated the cell cycle inhibitor p27. Cycloheximide decay assays showed that Akt2 increased the stability and nuclear localization of p27, thus inhibiting the cyclin E/CDK2 complex. These results suggest that the inhibition of cell proliferation by Akt1 and Akt2 is mediated by isoform-specific mechanisms. | - |
dc.language | 영어 | - |
dc.language.iso | en | - |
dc.publisher | ELSEVIER SCIENCE INC | - |
dc.title | Akt isoform-specific inhibition of MDA-MB-231 cell proliferation | - |
dc.type | Article | - |
dc.contributor.affiliatedAuthor | Shin, Incheol | - |
dc.identifier.doi | 10.1016/j.cellsig.2010.07.016 | - |
dc.identifier.scopusid | 2-s2.0-77957851665 | - |
dc.identifier.wosid | 000284444600004 | - |
dc.identifier.bibliographicCitation | CELLULAR SIGNALLING, v.23, no.1, pp.19 - 26 | - |
dc.relation.isPartOf | CELLULAR SIGNALLING | - |
dc.citation.title | CELLULAR SIGNALLING | - |
dc.citation.volume | 23 | - |
dc.citation.number | 1 | - |
dc.citation.startPage | 19 | - |
dc.citation.endPage | 26 | - |
dc.type.rims | ART | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
dc.description.isOpenAccess | N | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Cell Biology | - |
dc.relation.journalWebOfScienceCategory | Cell Biology | - |
dc.subject.keywordPlus | PROTEIN-KINASE-B | - |
dc.subject.keywordPlus | EPITHELIAL-MESENCHYMAL TRANSITION | - |
dc.subject.keywordPlus | GLUCOSE-HOMEOSTASIS | - |
dc.subject.keywordPlus | MICE LACKING | - |
dc.subject.keywordPlus | CYCLE PROGRESSION | - |
dc.subject.keywordPlus | DOWN-REGULATION | - |
dc.subject.keywordPlus | DISTINCT ROLES | - |
dc.subject.keywordPlus | HUMAN CANCER | - |
dc.subject.keywordPlus | IN-VITRO | - |
dc.subject.keywordPlus | PATHWAY | - |
dc.subject.keywordAuthor | Akt isoforms | - |
dc.subject.keywordAuthor | Breast cancer | - |
dc.subject.keywordAuthor | CDK2 | - |
dc.subject.keywordAuthor | ERK | - |
dc.subject.keywordAuthor | p27 | - |
dc.identifier.url | https://www.sciencedirect.com/science/article/pii/S0898656810002093?via%3Dihub | - |
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