Egr-1 is required for neu/HER2-induced mammary tumors
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Oh, Sunhwa | - |
dc.contributor.author | Kim, Hyungjoo | - |
dc.contributor.author | Nam, Keesoo | - |
dc.contributor.author | Shin, Incheol | - |
dc.date.accessioned | 2021-08-02T13:30:07Z | - |
dc.date.available | 2021-08-02T13:30:07Z | - |
dc.date.created | 2021-05-12 | - |
dc.date.issued | 2018-05 | - |
dc.identifier.issn | 0898-6568 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/hanyang/handle/2021.sw.hanyang/17001 | - |
dc.description.abstract | Egr-1 is known to function mainly as a tumor suppressor through direct regulation of multiple tumor suppressor genes. To determine the role of Egr-1 in breast tumors in vivo, we used mouse models of breast cancer induced by HER2/neu. We compared neu-overexpressing Egr-1 knockout mice (neu/Egr-1 KO) to neu-overexpressing Egr-1 wild type or heterozygote mice (neu/Egr-1 WT or neu/Egr-1 het) with regard to onset of tumor appearance and number of tumors per mouse. In addition, to examine the role of Egr-1 in vitro, we established neu/Egr-1 WT and KO tumor cell lines derived from breast tumors developed in each mouse. Egr-1 deletion delayed tumor development in vivo and decreased the rate of cell growth in vitro. These results suggest that Egr-1 plays an oncogenic role in HER2/neu-driven mammary tumorigenesis. | - |
dc.language | 영어 | - |
dc.language.iso | en | - |
dc.publisher | ELSEVIER SCIENCE INC | - |
dc.title | Egr-1 is required for neu/HER2-induced mammary tumors | - |
dc.type | Article | - |
dc.contributor.affiliatedAuthor | Shin, Incheol | - |
dc.identifier.doi | 10.1016/j.cellsig.2018.02.003 | - |
dc.identifier.scopusid | 2-s2.0-85041709679 | - |
dc.identifier.wosid | 000429764500010 | - |
dc.identifier.bibliographicCitation | CELLULAR SIGNALLING, v.45, pp.102 - 109 | - |
dc.relation.isPartOf | CELLULAR SIGNALLING | - |
dc.citation.title | CELLULAR SIGNALLING | - |
dc.citation.volume | 45 | - |
dc.citation.startPage | 102 | - |
dc.citation.endPage | 109 | - |
dc.type.rims | ART | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
dc.description.isOpenAccess | N | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Cell Biology | - |
dc.relation.journalWebOfScienceCategory | Cell Biology | - |
dc.subject.keywordPlus | EARLY GROWTH RESPONSE-1 | - |
dc.subject.keywordPlus | HUMAN-BREAST-CANCER | - |
dc.subject.keywordPlus | CELL LUNG-CANCER | - |
dc.subject.keywordPlus | CYCLIN D1 | - |
dc.subject.keywordPlus | SIGNAL TRANSDUCERS | - |
dc.subject.keywordPlus | TRANSCRIPTION | - |
dc.subject.keywordPlus | EXPRESSION | - |
dc.subject.keywordPlus | SURVIVAL | - |
dc.subject.keywordPlus | NOTCH | - |
dc.subject.keywordPlus | GENE | - |
dc.subject.keywordAuthor | Egr-1 | - |
dc.subject.keywordAuthor | Neu | - |
dc.subject.keywordAuthor | HER2 | - |
dc.subject.keywordAuthor | Mammary tumors | - |
dc.identifier.url | https://linkinghub.elsevier.com/retrieve/pii/S0898656818300366 | - |
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