Pd-Catalyzed Regioselective Intramolecular Allylic C-H Amination of 1,1-Disubstituted Alkenyl Amines br

Abstract

Pd-Catalyzed intramolecular allylic C-H aminationof 1,1-disubstituted alkenyl amines with various allylic tethers (X =O, NMs, CH2) was developed. This process allows for thedivergent synthesis of 1,3-X,N-heterocycles through a regioselectiveallylic C-H cleavage and pi-allylpalladium formation. Particularlynoteworthy is the use of substrates containing a labile allylic moietyand new simple catalytic systems capable of promoting highlychemo- and regioselective allylic C-H amination by overcomingsignificant challenges.