House dust mite-induced Akt-ERK1/2-C/EBP beta pathway triggers CCL20-mediated inflammation and epithelial-mesenchymal transition for airway remodeling
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Park, Shin-Young | - |
dc.contributor.author | Kang, Min-Jeong | - |
dc.contributor.author | Jin, Nuri | - |
dc.contributor.author | Lee, So Young | - |
dc.contributor.author | Lee, Yun Young | - |
dc.contributor.author | Jo, Sungsin | - |
dc.contributor.author | Eom, Jeong Yun | - |
dc.contributor.author | Han, Heejae | - |
dc.contributor.author | Chung, Sook In | - |
dc.contributor.author | Jang, Kiseok | - |
dc.contributor.author | Kim, Tae-Hwan | - |
dc.contributor.author | Park, Jungwon | - |
dc.contributor.author | Han, Joong-Soo | - |
dc.date.accessioned | 2022-09-19T11:31:46Z | - |
dc.date.available | 2022-09-19T11:31:46Z | - |
dc.date.created | 2022-09-08 | - |
dc.date.issued | 2022-09 | - |
dc.identifier.issn | 0892-6638 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/hanyang/handle/2021.sw.hanyang/171448 | - |
dc.description.abstract | House dust mite (HDM) allergens cause inflammatory responses and chronic allergic diseases such as bronchial asthma and atopic dermatitis. Here, we investigate the mechanism by which HDM induces C-C chemokine ligand 20 (CCL20) expression to promote chronic inflammation and airway remodeling in an HDM-induced bronchial asthma mouse model. We showed that HDM increased CCL20 levels via the Akt-ERK1/2-C/EBP beta pathway. To investigate the role of CCL20 in chronic airway inflammation and remodeling, we made a mouse model of CCL20-induced bronchial asthma. Treatment of anti-CCL20Ab in this mouse model showed the reduced airway hyper-responsiveness and inflammatory cell infiltration into peribronchial region by neutralizing CCL20. In addition, CCL20 induced the Nod-like receptor family, pyrin domain containing 3 (NLRP3) inflammasome activation through NLRP3 deubiquitination and transcriptional upregulation in BEAS-2B cells. As expected, anti-CCL20Ab markedly suppressed NLRP3 activation induced by CCL20. Moreover, HDM-induced CCL20 leads to epithelial-mesenchymal transition in the lung epithelium which appears to be an important regulator of airway remodeling in allergic asthma. We also found that anti-CCL20Ab attenuates airway inflammation and remodeling in an HDM-induced mouse model of bronchial asthma. Taken together, our results suggest that HDM-induced CCL20 is required for chronic inflammation that contributes airway remodeling in a mouse model of asthma. | - |
dc.language | 영어 | - |
dc.language.iso | en | - |
dc.publisher | WILEY | - |
dc.title | House dust mite-induced Akt-ERK1/2-C/EBP beta pathway triggers CCL20-mediated inflammation and epithelial-mesenchymal transition for airway remodeling | - |
dc.type | Article | - |
dc.contributor.affiliatedAuthor | Jang, Kiseok | - |
dc.contributor.affiliatedAuthor | Kim, Tae-Hwan | - |
dc.contributor.affiliatedAuthor | Han, Joong-Soo | - |
dc.identifier.doi | 10.1096/fj.202200150RR | - |
dc.identifier.scopusid | 2-s2.0-85135338599 | - |
dc.identifier.wosid | 000834764400001 | - |
dc.identifier.bibliographicCitation | FASEB JOURNAL, v.36, no.9, pp.1 - 19 | - |
dc.relation.isPartOf | FASEB JOURNAL | - |
dc.citation.title | FASEB JOURNAL | - |
dc.citation.volume | 36 | - |
dc.citation.number | 9 | - |
dc.citation.startPage | 1 | - |
dc.citation.endPage | 19 | - |
dc.type.rims | ART | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
dc.description.isOpenAccess | N | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Biochemistry & Molecular Biology | - |
dc.relation.journalResearchArea | Life Sciences & Biomedicine - Other Topics | - |
dc.relation.journalResearchArea | Cell Biology | - |
dc.relation.journalWebOfScienceCategory | Biochemistry & Molecular Biology | - |
dc.relation.journalWebOfScienceCategory | Biology | - |
dc.relation.journalWebOfScienceCategory | Cell Biology | - |
dc.subject.keywordPlus | INNATE IMMUNE ACTIVATION | - |
dc.subject.keywordPlus | GROWTH-FACTOR-BETA | - |
dc.subject.keywordPlus | NLRP3 INFLAMMASOME | - |
dc.subject.keywordPlus | PULMONARY INFLAMMATION | - |
dc.subject.keywordPlus | NALP3 INFLAMMASOME | - |
dc.subject.keywordPlus | ASTHMA | - |
dc.subject.keywordPlus | CELLS | - |
dc.subject.keywordPlus | CCL20 | - |
dc.subject.keywordPlus | FIBROSIS | - |
dc.subject.keywordPlus | RECRUITMENT | - |
dc.subject.keywordAuthor | airway remodeling | - |
dc.subject.keywordAuthor | asthma | - |
dc.subject.keywordAuthor | CCL20 (C-C chemokine ligand 20) | - |
dc.subject.keywordAuthor | house dust mites | - |
dc.subject.keywordAuthor | NLRP3 (Nod-like receptor family pyrin domain containing 3 | - |
dc.identifier.url | https://faseb.onlinelibrary.wiley.com/doi/10.1096/fj.202200150RR | - |
Items in ScholarWorks are protected by copyright, with all rights reserved, unless otherwise indicated.
222, Wangsimni-ro, Seongdong-gu, Seoul, 04763, Korea+82-2-2220-1365
COPYRIGHT © 2021 HANYANG UNIVERSITY.
Certain data included herein are derived from the © Web of Science of Clarivate Analytics. All rights reserved.
You may not copy or re-distribute this material in whole or in part without the prior written consent of Clarivate Analytics.