A Promising Review on Cyclodextrin Conjugated Paclitaxel Nanoparticles for Cancer Treatment
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Velhal, Kamini | - |
dc.contributor.author | Barage, Sagar | - |
dc.contributor.author | Roy, Arpita | - |
dc.contributor.author | Lakkakula, Jaya | - |
dc.contributor.author | Yamgar, Ramesh | - |
dc.contributor.author | Alqahtani, Mohammed S. | - |
dc.contributor.author | Yadav, Krishna Kumar | - |
dc.contributor.author | Ahn, Yongtae | - |
dc.contributor.author | Jeon, Byong-Hun | - |
dc.date.accessioned | 2022-09-19T12:13:41Z | - |
dc.date.available | 2022-09-19T12:13:41Z | - |
dc.date.created | 2022-09-08 | - |
dc.date.issued | 2022-08 | - |
dc.identifier.issn | 2073-4360 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/hanyang/handle/2021.sw.hanyang/171521 | - |
dc.description.abstract | This review presented the unique characteristics of different types of cyclodextrin polymers by non-covalent host-guest interactions to synthesize an inclusion complex. Various cancers are treated with different types of modified cyclodextrins, along with the anticancer drug paclitaxel. PTX acts as a mitotic inhibitor, but due to its low dissolution and permeability in aqueous solutions, it causes considerable challenges for drug delivery system (DDS) designs. To enhance the solubility, it is reformulated with derivatives of cyclodextrins using freeze-drying and co-solvent lyophilization methods. The present supramolecular assemblies involve cyclodextrin as a key mediator, which is encapsulated with paclitaxel and their controlled release at the targeted area is highlighted using different DDS. In addition, the application of cyclodextrins in cancer treatment, which reduces the off-target effects, is briefly demonstrated using various types of cancer cell lines. A new nano-formulation of PTX is used to improve the antitumor activity compared to normal PTX DDS in lungs and breast cancer is well defined in the present review. | - |
dc.language | 영어 | - |
dc.language.iso | en | - |
dc.publisher | MDPI | - |
dc.title | A Promising Review on Cyclodextrin Conjugated Paclitaxel Nanoparticles for Cancer Treatment | - |
dc.type | Article | - |
dc.contributor.affiliatedAuthor | Jeon, Byong-Hun | - |
dc.identifier.doi | 10.3390/polym14153162 | - |
dc.identifier.scopusid | 2-s2.0-85137103817 | - |
dc.identifier.wosid | 000839047300001 | - |
dc.identifier.bibliographicCitation | POLYMERS, v.14, no.15, pp.1 - 20 | - |
dc.relation.isPartOf | POLYMERS | - |
dc.citation.title | POLYMERS | - |
dc.citation.volume | 14 | - |
dc.citation.number | 15 | - |
dc.citation.startPage | 1 | - |
dc.citation.endPage | 20 | - |
dc.type.rims | ART | - |
dc.type.docType | Review | - |
dc.description.journalClass | 1 | - |
dc.description.isOpenAccess | Y | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Polymer Science | - |
dc.relation.journalWebOfScienceCategory | Polymer Science | - |
dc.subject.keywordPlus | SOLID LIPID NANOPARTICLES | - |
dc.subject.keywordPlus | CHITOSAN NANOPARTICLES | - |
dc.subject.keywordPlus | CONTROLLED-RELEASE | - |
dc.subject.keywordPlus | DELIVERY | - |
dc.subject.keywordPlus | INCLUSION | - |
dc.subject.keywordPlus | EFFICACY | - |
dc.subject.keywordPlus | CURCUMIN | - |
dc.subject.keywordPlus | POLYMER | - |
dc.subject.keywordPlus | COMPLEX | - |
dc.subject.keywordAuthor | paclitaxel PTX | - |
dc.subject.keywordAuthor | cyclodextrin CD | - |
dc.subject.keywordAuthor | nanoparticles NPs | - |
dc.subject.keywordAuthor | novel drug delivery system NDDS | - |
dc.identifier.url | https://www.mdpi.com/2073-4360/14/15/3162 | - |
Items in ScholarWorks are protected by copyright, with all rights reserved, unless otherwise indicated.
222, Wangsimni-ro, Seongdong-gu, Seoul, 04763, Korea+82-2-2220-1365
COPYRIGHT © 2021 HANYANG UNIVERSITY.
Certain data included herein are derived from the © Web of Science of Clarivate Analytics. All rights reserved.
You may not copy or re-distribute this material in whole or in part without the prior written consent of Clarivate Analytics.