Association between Age of Onset of Hypertension and Incident Atrial Fibrillationopen access
- Authors
- Lee, Yonggu; Shin, Jeong-Hun; Kim, Byung Sik; Kook, Hyungdon; Kim, Woohyeun; Heo, Ran; Lim, Young-Hyo; Shin, Jinho; Kim, Chun Ki; Park, Jin-Kyu
- Issue Date
- Jul-2022
- Publisher
- MDPI
- Keywords
- early-onset hypertension; atrial fibrillation; Ansan-Ansung cohort
- Citation
- JOURNAL OF PERSONALIZED MEDICINE, v.12, no.7, pp.1 - 12
- Indexed
- SCIE
SCOPUS
- Journal Title
- JOURNAL OF PERSONALIZED MEDICINE
- Volume
- 12
- Number
- 7
- Start Page
- 1
- End Page
- 12
- URI
- https://scholarworks.bwise.kr/hanyang/handle/2021.sw.hanyang/171585
- DOI
- 10.3390/jpm12071186
- ISSN
- 2075-4426
- Abstract
- We investigated whether age at hypertension (HTN) onset was associated with the risk of atrial fibrillation (AF) in the general population. This prospective longitudinal community-based cohort study included 9892 participants without AF at baseline, who underwent biennial electrocardiography for a median duration of 11.5 years. The participants were divided into five groups, consisting of a normotensive group (Group-N) and four HTN groups based on HTN onset age: <45 years (Group-H1); 45-54 years (Group-H2); 55-64 years (Group-H3); and >= 65 years (Group-H4). A multivariate Cox proportional hazards model showed that the presence of HTN at baseline was associated with higher AF risk (hazard ratio [HR], 1.93; 95% confidence interval [CI] 1.32-2.80). The participants in Group-H1 had the highest risk of AF (HR 3.18; CI 1.74-5.82), and the risk of AF decreased as HTN onset age increased across the four HTN groups (p for trend = 0.014). The AF onset age was significantly younger in participants in Group-H1 than in Groups-H2-H4. Early-onset HTN was associated with an increased risk of AF, and younger onset of AF in the general population. Surveillance for AF should be considered at a younger age in individuals with HTN.
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