Detailed Information
Cited 0 time in 
Cited 0 time in 
Cited 0 time in
Metadata Downloads
Bleomycin에 의한 경피증 동물모델 유도open accessInduction of Animal Model of Scleroderma with Repeated Injection of Bleomycin
- Other Titles
- Induction of Animal Model of Scleroderma with Repeated Injection of Bleomycin
- Issue Date
- Jun-2009
- Publisher
- 대한류마티스학회
- Keywords
- Scleroderma; Animal model; Bleomycin; Scleroderma; Animal model; Bleomycin
- Citation
- 대한류마티스학회지, v.16, no.2, pp.95 - 99
- Indexed
- KCI
- Journal Title
- 대한류마티스학회지
- Volume
- 16
- Number
- 2
- Start Page
- 95
- End Page
- 99
- ISSN
- 2093-940X
- Abstract
- Objective: To induce a mouse model of scleroderma with repeated bleomycin injections for research into human scleroderma at our research laboratory. Methods: The protocol of Yamamoto et al. was replicated to establish the bleomycin-induced mouse model of scleroderma. Results: A mouse model of scleroderma was induced by repeated subcutaneous injections of bleomycin. The dermal thickness increased with homogeneous and thickened collagen bundles. Semiquantitative measurements of dermal fibrosis were prominent in bleomycin-treated mice. Conclusion: A mouse model of scleroderma was induced with repeated injections of bleomycin at our laboratory.
- Files in This Item
- Appears in
Collections - 서울 의과대학 > 서울 내과학교실 > 1. Journal Articles
- 서울 의과대학 > 서울 병리학교실 > 1. Journal Articles
Items in ScholarWorks are protected by copyright, with all rights reserved, unless otherwise indicated.
Related Researcher
- Jun, Jae Bum
- COLLEGE OF MEDICINE (DEPARTMENT OF INTERNAL MEDICINE)