Treating lithium-induced nephrogenic diabetes insipidus with a COX-2 inhibitor improves polyuria via upregulation of AQP2 and NKCC2
DC Field | Value | Language |
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dc.contributor.author | Kim, Gheun-Ho | - |
dc.contributor.author | Choi, Nak Won | - |
dc.contributor.author | Jung, Ju-Young | - |
dc.contributor.author | Song, Ji-Hyun | - |
dc.contributor.author | Lee, Chang Hwa | - |
dc.contributor.author | Kang, Chong Myung | - |
dc.contributor.author | Knepper, Mark A. | - |
dc.date.accessioned | 2022-10-07T10:34:37Z | - |
dc.date.available | 2022-10-07T10:34:37Z | - |
dc.date.created | 2022-08-26 | - |
dc.date.issued | 2008-04 | - |
dc.identifier.issn | 1931-857X | - |
dc.identifier.uri | https://scholarworks.bwise.kr/hanyang/handle/2021.sw.hanyang/172096 | - |
dc.description.abstract | Prostaglandin E-2 may antagonize vasopressin-stimulated salt absorption in the thick ascending limb and water absorption in the collecting duct. Blockade of prostaglandin E2 synthesis by nonsteroidal anti-inflammatory drugs (NSAIDs) enhances urinary concentration, and these agents have antidiuretic effects in patients with nephrogenic diabetes insipidus (NDI) of different etiologies. Because renal prostaglandins are derived largely from cyclooxygenase-2 (COX-2), we hypothesized that treatment of NDI with a COX-2 inhibitor may relieve polyuria through increased expression of Na-K-2Cl cotransporter type 2 (NKCC2) in the thick ascending limb and aquaporin-2 (AQP2) in the collecting duct. To test this hypothesis, semiquantitative immunoblotting and immunohistochemistry were carried out from the kidneys of lithium-induced NDI rats with and without COX-2 inhibition. After male Sprague-Dawley rats were fed an LiCl-containing rat diet for 3 wk, the rats were randomly divided into control and experimental groups. The COX-2 inhibitor DFU (40 mg center dot kg(-1) center dot day(-1)) was orally administered to the experimental rats for an additional week. Treatment with the COX-2 inhibitor significantly relieved polyuria and raised urine osmolality. Semiquantitative immunoblotting using whole-kidney homogenates revealed that COX-2 inhibition caused significant increases in the abundance of AQP2 and NKCC2. Immunohistochemistry for AQP2 and NKCC2 confirmed the effects of COX-2 inhibition in lithium-induced NDI rats. The upregulation of AQP2 and NKCC2 in response to the COX-2 inhibitor may underlie the therapeutic mechanisms by which NSAIDs enhance antidiuresis in patients with NDI. | - |
dc.language | 영어 | - |
dc.language.iso | en | - |
dc.publisher | AMER PHYSIOLOGICAL SOC | - |
dc.title | Treating lithium-induced nephrogenic diabetes insipidus with a COX-2 inhibitor improves polyuria via upregulation of AQP2 and NKCC2 | - |
dc.type | Article | - |
dc.contributor.affiliatedAuthor | Kim, Gheun-Ho | - |
dc.contributor.affiliatedAuthor | Lee, Chang Hwa | - |
dc.identifier.doi | 10.1152/ajprenal.00366.2007 | - |
dc.identifier.scopusid | 2-s2.0-44949231366 | - |
dc.identifier.wosid | 000254623200003 | - |
dc.identifier.bibliographicCitation | AMERICAN JOURNAL OF PHYSIOLOGY-RENAL PHYSIOLOGY, v.294, no.4, pp.F702 - F709 | - |
dc.relation.isPartOf | AMERICAN JOURNAL OF PHYSIOLOGY-RENAL PHYSIOLOGY | - |
dc.citation.title | AMERICAN JOURNAL OF PHYSIOLOGY-RENAL PHYSIOLOGY | - |
dc.citation.volume | 294 | - |
dc.citation.number | 4 | - |
dc.citation.startPage | F702 | - |
dc.citation.endPage | F709 | - |
dc.type.rims | ART | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
dc.description.isOpenAccess | Y | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Physiology | - |
dc.relation.journalResearchArea | Urology & Nephrology | - |
dc.relation.journalWebOfScienceCategory | Physiology | - |
dc.relation.journalWebOfScienceCategory | Urology & Nephrology | - |
dc.subject.keywordPlus | THICK ASCENDING LIMB | - |
dc.subject.keywordPlus | NA-K-2CL COTRANSPORTER ABUNDANCE | - |
dc.subject.keywordPlus | CORTICAL COLLECTING DUCT | - |
dc.subject.keywordPlus | PROSTAGLANDIN SYNTHESIS | - |
dc.subject.keywordPlus | SODIUM-TRANSPORT | - |
dc.subject.keywordPlus | DOWN-REGULATION | - |
dc.subject.keywordPlus | WATER CHANNEL | - |
dc.subject.keywordPlus | TOAD BLADDER | - |
dc.subject.keywordPlus | RENAL WATER | - |
dc.subject.keywordPlus | HENLES LOOP | - |
dc.subject.keywordAuthor | cyclooxygenase-2 | - |
dc.subject.keywordAuthor | lithium | - |
dc.subject.keywordAuthor | aquaporin-2 | - |
dc.subject.keywordAuthor | Na-K-2Cl cotransporter | - |
dc.subject.keywordAuthor | DFU | - |
dc.identifier.url | https://journals.physiology.org/doi/full/10.1152/ajprenal.00366.2007 | - |
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