CD24 cross-linking induces apoptosis in, and inhibits migration of, MCF-7 breast cancer cells
DC Field | Value | Language |
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dc.contributor.author | Kim, Jong Bin | - |
dc.contributor.author | Ko, Eunyoung | - |
dc.contributor.author | Han, Wonshik | - |
dc.contributor.author | Lee, Jeong Eon | - |
dc.contributor.author | Lee, Kyung-Min | - |
dc.contributor.author | Shin, Incheol | - |
dc.contributor.author | Kim, Sangmin | - |
dc.contributor.author | Lee, Jong Won | - |
dc.contributor.author | Cho, Jihyoung | - |
dc.contributor.author | Bae, Ji-Yeon | - |
dc.contributor.author | Jee, Hyeon-Gun | - |
dc.contributor.author | Noh, Dong-Young | - |
dc.date.accessioned | 2022-10-07T10:35:40Z | - |
dc.date.available | 2022-10-07T10:35:40Z | - |
dc.date.created | 2022-08-26 | - |
dc.date.issued | 2008-04 | - |
dc.identifier.issn | 1471-2407 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/hanyang/handle/2021.sw.hanyang/172105 | - |
dc.description.abstract | Background: The biological effects of CD24 (FL-80) cross-linking on breast cancer cells have not yet been established. We examined the impact of CD24 cross-linking on human breast cancer cell line MCF-7. Methods: MCF-7 and MDA-MB-231 cells were treated with anti-rabbit polyclonal IgG or anti-human CD24 rabbit polyclonal antibodies to induce cross-linking, and then growth was studied. Changes in cell characteristics such as cell cycle modulation, cell death, survival in three-dimensional cultures, adhesion, and migration ability were assayed after CD24 cross-linking in MCF-7. Results: Expression of CD24 was analyzed by flow cytometry in MDA-MB-231 and MCF-7 cells where 2% and 66% expression frequencies were observed, respectively. CD24 cross-linking resulted in time-dependent proliferation reduction in MCF-7 cells, but no reduction in MDA-MB-231 cells. MCF-7 cell survival was reduced by 15% in three-dimensional culture after CD24 cross-linking. Increased MCF-7 cell apoptosis was observed after CD24 cross-linking, but no cell cycle arrest was observed in that condition. The migration capacity of MCF-7 cells was diminished by 30% after CD24 cross-linking. Conclusion: Our results showed that CD24 cross-linking induced apoptosis and inhibited migration in MCF-7 breast cancer cells. We conclude that CD24 may be considered as a novel therapeutic target for breast cancer. | - |
dc.language | 영어 | - |
dc.language.iso | en | - |
dc.publisher | BMC | - |
dc.title | CD24 cross-linking induces apoptosis in, and inhibits migration of, MCF-7 breast cancer cells | - |
dc.type | Article | - |
dc.contributor.affiliatedAuthor | Shin, Incheol | - |
dc.identifier.doi | 10.1186/1471-2407-8-118 | - |
dc.identifier.scopusid | 2-s2.0-44149121701 | - |
dc.identifier.wosid | 000255939200001 | - |
dc.identifier.bibliographicCitation | BMC CANCER, v.8, pp.1 - 10 | - |
dc.relation.isPartOf | BMC CANCER | - |
dc.citation.title | BMC CANCER | - |
dc.citation.volume | 8 | - |
dc.citation.startPage | 1 | - |
dc.citation.endPage | 10 | - |
dc.type.rims | ART | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
dc.description.isOpenAccess | Y | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Oncology | - |
dc.relation.journalWebOfScienceCategory | Oncology | - |
dc.subject.keywordPlus | FUNCTIONAL MAMMARY-GLAND | - |
dc.subject.keywordPlus | HEAT-STABLE ANTIGEN | - |
dc.subject.keywordPlus | EXPRESSION | - |
dc.subject.keywordPlus | BINDING | - |
dc.subject.keywordPlus | CARCINOMA | - |
dc.subject.keywordPlus | ESTROGEN | - |
dc.subject.keywordPlus | MARKER | - |
dc.subject.keywordPlus | GROWTH | - |
dc.subject.keywordPlus | IDENTIFICATION | - |
dc.subject.keywordPlus | GENE | - |
dc.identifier.url | https://bmccancer.biomedcentral.com/articles/10.1186/1471-2407-8-118 | - |
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