Reduced expression of Apaf-1 in colorectal adenocarcinoma correlates with tumor progression and aggressive phenotype
DC Field | Value | Language |
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dc.contributor.author | Paik, Seung Sam | - |
dc.contributor.author | Jang, Ki-Seok | - |
dc.contributor.author | Song, Young Soo | - |
dc.contributor.author | Jang, Si-Hyong | - |
dc.contributor.author | Min, Kyueng-Whan | - |
dc.contributor.author | Han, Hong Xiu | - |
dc.contributor.author | Na, Woong | - |
dc.contributor.author | Lee, Kang Hong | - |
dc.contributor.author | Choi, Dongho | - |
dc.contributor.author | Jang, Se Jin | - |
dc.date.accessioned | 2022-10-07T10:46:35Z | - |
dc.date.available | 2022-10-07T10:46:35Z | - |
dc.date.created | 2022-08-26 | - |
dc.date.issued | 2007-12 | - |
dc.identifier.issn | 1068-9265 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/hanyang/handle/2021.sw.hanyang/172203 | - |
dc.description.abstract | Background: Apoptotic protease activating factor-1 (Apaf-1) is one of the key regulators in the mitochondrial apoptotic pathway, and the loss of Apaf-1 leads to cellular resistance against the apoptotic signals. We investigated the expression of Apaf-1 in colorectal tissues corresponding to the multistep carcinogenesis model to determine correlations between the clinicopathologic characteristics and the expression of this molecule and to evaluate the role of Apaf-1 in the development and progression of colorectal adenocarcinoma. Methods: Immunohistochemistry for Apaf-1 was performed on the tissue microarray of 38 normal mucosal tissues, 46 adenomatous polyps, 529 colorectal adenocarcinomas, and 76 metastatic tumors. Results: Normal colonic mucosa tissues and adenomas were positive for Apaf-1 with no exceptions (100%). However, in colorectal adenocarcinomas, 119 of 529 cases (22.5%) were positive and 410 cases (77.5%) were negative. Moreover, 67 of 76 metastatic cases (88.2 %) were negative and only nine cases (11.8%) were positive for Apaf-1 expression. In the analyses between Apaf-1 expression and clinicopathologic parameters, reduced expression of Apaf-1 correlated with left colon location (p < 0.001), deeper tumor invasion (p < 0.001), frequent lymph node metastasis ( p= 0.021), higher American Joint Committee on Cancer (AJCC) and Dukes' stage (p = 0.02 and p = 0.001, respectively) and poorer differentiation (p < 0.001). The patient survival was significantly associated with age, histological grade, AJCC stage, and lymphovascular invasion, but not Apaf-1 expression (p = 0.478). Conclusions: The results suggest that the loss of Apaf-1 expression is a relatively frequent late event and the loss of Apaf-1 expression may play an important role in tumorigenesis and tumor progression in colorectal adenocarcinoma. | - |
dc.language | 영어 | - |
dc.language.iso | en | - |
dc.publisher | SPRINGER | - |
dc.title | Reduced expression of Apaf-1 in colorectal adenocarcinoma correlates with tumor progression and aggressive phenotype | - |
dc.type | Article | - |
dc.contributor.affiliatedAuthor | Paik, Seung Sam | - |
dc.contributor.affiliatedAuthor | Jang, Ki-Seok | - |
dc.contributor.affiliatedAuthor | Min, Kyueng-Whan | - |
dc.contributor.affiliatedAuthor | Lee, Kang Hong | - |
dc.contributor.affiliatedAuthor | Choi, Dongho | - |
dc.identifier.doi | 10.1245/s10434-007-9541-2 | - |
dc.identifier.scopusid | 2-s2.0-36348973429 | - |
dc.identifier.wosid | 000250976500028 | - |
dc.identifier.bibliographicCitation | ANNALS OF SURGICAL ONCOLOGY, v.14, no.12, pp.3453 - 3459 | - |
dc.relation.isPartOf | ANNALS OF SURGICAL ONCOLOGY | - |
dc.citation.title | ANNALS OF SURGICAL ONCOLOGY | - |
dc.citation.volume | 14 | - |
dc.citation.number | 12 | - |
dc.citation.startPage | 3453 | - |
dc.citation.endPage | 3459 | - |
dc.type.rims | ART | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
dc.description.isOpenAccess | N | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Oncology | - |
dc.relation.journalResearchArea | Surgery | - |
dc.relation.journalWebOfScienceCategory | Oncology | - |
dc.relation.journalWebOfScienceCategory | Surgery | - |
dc.subject.keywordPlus | MELANOMA PROGRESSION | - |
dc.subject.keywordPlus | CUTANEOUS MELANOMA | - |
dc.subject.keywordPlus | ALLELIC IMBALANCE | - |
dc.subject.keywordPlus | APOPTOSIS | - |
dc.subject.keywordPlus | CANCER | - |
dc.subject.keywordPlus | CARCINOMA | - |
dc.subject.keywordPlus | PROGNOSIS | - |
dc.subject.keywordPlus | THERAPY | - |
dc.subject.keywordPlus | LOCUS | - |
dc.subject.keywordAuthor | colorectal cancer | - |
dc.subject.keywordAuthor | apoptosis | - |
dc.subject.keywordAuthor | apoptotic protease activating factor 1 | - |
dc.subject.keywordAuthor | tumor progression | - |
dc.identifier.url | https://link.springer.com/article/10.1245/s10434-007-9541-2 | - |
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