Reliable and fast quantitative analysis of active ingredient in pharmaceutical suspension using Raman spectroscopy
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Park, Seok Chan | - |
dc.contributor.author | Kim, Minjung | - |
dc.contributor.author | Noh, Jaegeun | - |
dc.contributor.author | Chung, Hoeil | - |
dc.contributor.author | Woo, Youngah | - |
dc.contributor.author | Lee, Jonghwa | - |
dc.contributor.author | Kemper, Mark S. | - |
dc.date.accessioned | 2022-10-07T11:27:59Z | - |
dc.date.available | 2022-10-07T11:27:59Z | - |
dc.date.created | 2022-08-26 | - |
dc.date.issued | 2007-06 | - |
dc.identifier.issn | 0003-2670 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/hanyang/handle/2021.sw.hanyang/172296 | - |
dc.description.abstract | The concentration of acetaminophen in a turbid pharmaceutical suspension has been measured successfully using Raman spectroscopy. The spectrometer was equipped with a large spot probe which enabled the coverage of a representative area during sampling. This wide area illumination (WAI) scheme (coverage area 28.3 mm(2)) for Raman data collection proved to be more reliable for the compositional determination of these pharmaceutical suspensions, especially when the samples were turbid. The reproducibility of measurement using the WAI scheme was compared to that of using a conventional small-spot scheme which employed a much smaller illumination area (about 100 mu m spot size). A layer of isobutyric anhydride was placed in front of the sample vials to correct the variation in the Raman intensity due to the fluctuation of laser power. Corrections were accomplished using the isolated carbonyl band of isobutyric anhydride. The acetaminophen concentrations of prediction samples were accurately estimated using a partial least squares (PLS) calibration model. The prediction accuracy was maintained even with changes in laser power. It was noted that the prediction performance was somewhat degraded for turbid suspensions with high acetaminophen contents. When comparing the results of reproducibility obtained with the WAI scheme and those obtained using the conventional scheme, it was concluded that the quantitative determination of the active pharmaceutical ingredient (API) in turbid suspensions is much improved when employing a larger laser coverage area. This is presumably due to the improvement in representative sampling. | - |
dc.language | 영어 | - |
dc.language.iso | en | - |
dc.publisher | ELSEVIER | - |
dc.title | Reliable and fast quantitative analysis of active ingredient in pharmaceutical suspension using Raman spectroscopy | - |
dc.type | Article | - |
dc.contributor.affiliatedAuthor | Noh, Jaegeun | - |
dc.contributor.affiliatedAuthor | Chung, Hoeil | - |
dc.identifier.doi | 10.1016/j.aca.2007.04.056 | - |
dc.identifier.scopusid | 2-s2.0-34248643717 | - |
dc.identifier.wosid | 000247412600007 | - |
dc.identifier.bibliographicCitation | ANALYTICA CHIMICA ACTA, v.593, no.1, pp.46 - 53 | - |
dc.relation.isPartOf | ANALYTICA CHIMICA ACTA | - |
dc.citation.title | ANALYTICA CHIMICA ACTA | - |
dc.citation.volume | 593 | - |
dc.citation.number | 1 | - |
dc.citation.startPage | 46 | - |
dc.citation.endPage | 53 | - |
dc.type.rims | ART | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
dc.description.isOpenAccess | N | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Chemistry | - |
dc.relation.journalWebOfScienceCategory | Chemistry, Analytical | - |
dc.subject.keywordAuthor | acetoaminophen | - |
dc.subject.keywordAuthor | pharmaceutical suspension | - |
dc.subject.keywordAuthor | Raman spectroscopy | - |
dc.subject.keywordAuthor | wide area illumination | - |
dc.subject.keywordAuthor | process analytical technology | - |
dc.identifier.url | https://www.sciencedirect.com/science/article/pii/S0003267007008239?via%3Dihub | - |
Items in ScholarWorks are protected by copyright, with all rights reserved, unless otherwise indicated.
222, Wangsimni-ro, Seongdong-gu, Seoul, 04763, Korea+82-2-2220-1365
COPYRIGHT © 2021 HANYANG UNIVERSITY.
Certain data included herein are derived from the © Web of Science of Clarivate Analytics. All rights reserved.
You may not copy or re-distribute this material in whole or in part without the prior written consent of Clarivate Analytics.