Genetic causal inference between amblyopia and perinatal factors
DC Field | Value | Language |
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dc.contributor.author | Lee, Ju-Yeun | - |
dc.contributor.author | Lee, Sangjun | - |
dc.contributor.author | Park, Sue K. | - |
dc.date.accessioned | 2022-12-20T06:10:15Z | - |
dc.date.available | 2022-12-20T06:10:15Z | - |
dc.date.created | 2022-12-07 | - |
dc.date.issued | 2022-10 | - |
dc.identifier.issn | 2045-2322 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/hanyang/handle/2021.sw.hanyang/172950 | - |
dc.description.abstract | Amblyopia is a common visual disorder that causes significant vision problems globally. Most non-ocular risk factors for amblyopia are closely related to the intrauterine environment, and are strongly influenced by parent-origin effects. Parent-origin perinatal factors may have a direct causal inference on amblyopia development; therefore, we investigated the causal association between perinatal factors and amblyopia risk using a one-sample Mendelian Randomization (MR) with data from the UK Biobank Cohort Data (UKBB). Four distinct MR methods were employed to analyze the association between three perinatal factors (birth weight [BW], maternal smoking, and breastfeeding) and amblyopia risk, based on the summary statistics of genome-wide association studies in the European population. The inverse variance weighting method showed an inverse causal association between BW and amblyopia risk (odds ratio, 0.48 [95% CI, 0.29-0.80]; p = 0.004). Maternal smoking and breastfeeding were not causally associated with amblyopia risk. Our findings provided a possible evidence of a significant genetic causal association between low BW and increased amblyopia risk. This evidence may highlight the potential of BW as a predictive factor for visual maldevelopment and the need for careful management of amblyopia risk in patients with low BW. | - |
dc.language | 영어 | - |
dc.language.iso | en | - |
dc.publisher | NATURE PORTFOLIO | - |
dc.title | Genetic causal inference between amblyopia and perinatal factors | - |
dc.type | Article | - |
dc.contributor.affiliatedAuthor | Lee, Ju-Yeun | - |
dc.identifier.doi | 10.1038/s41598-022-22121-3 | - |
dc.identifier.scopusid | 2-s2.0-85140622854 | - |
dc.identifier.wosid | 000876924900072 | - |
dc.identifier.bibliographicCitation | SCIENTIFIC REPORTS, v.12, no.1, pp.1 - 7 | - |
dc.relation.isPartOf | SCIENTIFIC REPORTS | - |
dc.citation.title | SCIENTIFIC REPORTS | - |
dc.citation.volume | 12 | - |
dc.citation.number | 1 | - |
dc.citation.startPage | 1 | - |
dc.citation.endPage | 7 | - |
dc.type.rims | ART | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
dc.description.isOpenAccess | Y | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Science & Technology - Other Topics | - |
dc.relation.journalWebOfScienceCategory | Multidisciplinary Sciences | - |
dc.subject.keywordPlus | BIRTH-WEIGHT INFANTS | - |
dc.subject.keywordPlus | MENDELIAN RANDOMIZATION | - |
dc.subject.keywordPlus | RISK-FACTORS | - |
dc.subject.keywordPlus | VISION | - |
dc.subject.keywordPlus | PREVALENCE | - |
dc.subject.keywordPlus | CHILDREN | - |
dc.identifier.url | https://www.nature.com/articles/s41598-022-22121-3 | - |
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