Characterization of early-stage cutaneous radiation injury by using optical coherence tomography angiography
DC Field | Value | Language |
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dc.contributor.author | Lee, Jungbin | - |
dc.contributor.author | Jang, Won Hyuk | - |
dc.contributor.author | Shim, Sehwan | - |
dc.contributor.author | Kim, Bumju | - |
dc.contributor.author | Jang, Won-Suk | - |
dc.contributor.author | Myung, Jae Kyung | - |
dc.contributor.author | Park, Sunhoo | - |
dc.contributor.author | Kim, Ki Hean | - |
dc.date.accessioned | 2022-12-20T10:41:03Z | - |
dc.date.available | 2022-12-20T10:41:03Z | - |
dc.date.created | 2022-11-30 | - |
dc.date.issued | 2020-05 | - |
dc.identifier.issn | 2156-7085 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/hanyang/handle/2021.sw.hanyang/173269 | - |
dc.description.abstract | Cutaneous radiation injury (CRI) is a skin injury caused by exposure to high dose ionizing radiation (IR). Diagnosis and treatment of CRI is difficult due to its initial clinically latent period and the following inflammatory bursts. Early detection of CRI before clinical symptoms will be helpful for effective treatment, and various optical methods have been applied with limitations. Here we show that optical coherence tomography angiography (OCTA) could detect changes in the skin during the latent period in CRI mouse models non-invasively. CRI was induced on the mouse hindlimb with exposure to various IR doses and the injured skin regions were imaged longitudinally by OCTA until the onset of clinical symptoms. OCTA detected several changes in the skin including the skin thickening, the dilation of large blood vessels, and the irregularity in vessel boundaries. Some of OCTA findings were confirmed by histology. The study results showed that OCTA could be used for early CRI detection. | - |
dc.language | 영어 | - |
dc.language.iso | en | - |
dc.publisher | The Optical Society | - |
dc.title | Characterization of early-stage cutaneous radiation injury by using optical coherence tomography angiography | - |
dc.type | Article | - |
dc.contributor.affiliatedAuthor | Myung, Jae Kyung | - |
dc.identifier.doi | 10.1364/BOE.387400 | - |
dc.identifier.scopusid | 2-s2.0-85084671433 | - |
dc.identifier.wosid | 000532568000026 | - |
dc.identifier.bibliographicCitation | Biomedical Optics Express, v.11, no.5, pp.2652 - 2664 | - |
dc.relation.isPartOf | Biomedical Optics Express | - |
dc.citation.title | Biomedical Optics Express | - |
dc.citation.volume | 11 | - |
dc.citation.number | 5 | - |
dc.citation.startPage | 2652 | - |
dc.citation.endPage | 2664 | - |
dc.type.rims | ART | - |
dc.description.journalClass | 1 | - |
dc.description.isOpenAccess | Y | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Biochemistry & Molecular BiologyOptics | - |
dc.relation.journalResearchArea | Radiology, Nuclear Medicine & Medical Imaging | - |
dc.relation.journalWebOfScienceCategory | Biochemistry & Molecular BiologyOptics | - |
dc.relation.journalWebOfScienceCategory | Radiology, Nuclear Medicine & Medical Imaging | - |
dc.subject.keywordPlus | Angiography | - |
dc.subject.keywordPlus | Biological radiation effects | - |
dc.subject.keywordPlus | Ionizing radiation | - |
dc.subject.keywordPlus | Optical tomography | - |
dc.subject.keywordPlus | Tomography | - |
dc.identifier.url | https://opg.optica.org/boe/fulltext.cfm?uri=boe-11-5-2652&id=431055 | - |
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