Near Infrared Luminescent Oxygen Nanosensors with Nanoparticle Matrix Tailored Sensitivity
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Lee, Yong-Eun Koo | - |
dc.contributor.author | Ulbrich, Elyse E. | - |
dc.contributor.author | Kim, Gwangseong | - |
dc.contributor.author | Hah, Hoejin | - |
dc.contributor.author | Strollo, Christen | - |
dc.contributor.author | Fan, Wenzhe | - |
dc.contributor.author | Gurjar, Rajan | - |
dc.contributor.author | Koo, Sang Man | - |
dc.contributor.author | Kopelman, Raoul | - |
dc.date.accessioned | 2022-12-20T11:37:09Z | - |
dc.date.available | 2022-12-20T11:37:09Z | - |
dc.date.created | 2022-08-26 | - |
dc.date.issued | 2010-10 | - |
dc.identifier.issn | 0003-2700 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/hanyang/handle/2021.sw.hanyang/173667 | - |
dc.description.abstract | The development of sensors for noninvasive determination of oxygen levels in live cells and tissues is critical for the understanding of cellular functions, as well as for monitoring the status of disease, such as cancer, and for predicting the efficacy of therapy. We describe such nontoxic, targeted, and ratiometric 30 nm oxygen nanosensors made of polyacrylamide hydrogel, near-infrared (NIR) luminescent dyes, and surface-conjugated tumor-specific peptides. They enabled noninvasive real-time monitoring of oxygen levels in live cancer cells under normal and hypoxic conditions. The required sensitivity, brightness, selectivity, and stability were achieved by tailoring the interaction between the nanomatrix and indicator dyes. The developed nanosensors may become useful for in vivo oxygen measurements. | - |
dc.language | 영어 | - |
dc.language.iso | en | - |
dc.publisher | AMER CHEMICAL SOC | - |
dc.title | Near Infrared Luminescent Oxygen Nanosensors with Nanoparticle Matrix Tailored Sensitivity | - |
dc.type | Article | - |
dc.contributor.affiliatedAuthor | Koo, Sang Man | - |
dc.identifier.doi | 10.1021/ac1015358 | - |
dc.identifier.scopusid | 2-s2.0-77958027693 | - |
dc.identifier.wosid | 000282859100015 | - |
dc.identifier.bibliographicCitation | ANALYTICAL CHEMISTRY, v.82, no.20, pp.8446 - 8455 | - |
dc.relation.isPartOf | ANALYTICAL CHEMISTRY | - |
dc.citation.title | ANALYTICAL CHEMISTRY | - |
dc.citation.volume | 82 | - |
dc.citation.number | 20 | - |
dc.citation.startPage | 8446 | - |
dc.citation.endPage | 8455 | - |
dc.type.rims | ART | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
dc.description.isOpenAccess | Y | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Chemistry | - |
dc.relation.journalWebOfScienceCategory | Chemistry, Analytical | - |
dc.subject.keywordPlus | IN-VIVO | - |
dc.subject.keywordPlus | INTRACELLULAR OXYGEN | - |
dc.subject.keywordPlus | DISSOLVED-OXYGEN | - |
dc.subject.keywordPlus | FLUORESCENT NANOSENSORS | - |
dc.subject.keywordPlus | PHOSPHORESCENT PROBES | - |
dc.subject.keywordPlus | MOLECULAR-OXYGEN | - |
dc.subject.keywordPlus | EXTRACELLULAR PH | - |
dc.subject.keywordPlus | TUMOR HYPOXIA | - |
dc.subject.keywordPlus | LIVING CELLS | - |
dc.subject.keywordPlus | LIVE CELLS | - |
dc.identifier.url | https://pubs.acs.org/doi/10.1021/ac1015358 | - |
Items in ScholarWorks are protected by copyright, with all rights reserved, unless otherwise indicated.
222, Wangsimni-ro, Seongdong-gu, Seoul, 04763, Korea+82-2-2220-1365
COPYRIGHT © 2021 HANYANG UNIVERSITY.
Certain data included herein are derived from the © Web of Science of Clarivate Analytics. All rights reserved.
You may not copy or re-distribute this material in whole or in part without the prior written consent of Clarivate Analytics.