Cell-permeable Foxp3 protein alleviates autoimmune disease associated with inflammatory bowel disease and allergic airway inflammation
DC Field | Value | Language |
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dc.contributor.author | Choi, Je-Min | - |
dc.contributor.author | Shin, Jae-Hun | - |
dc.contributor.author | Sohn, Myung-Hyun | - |
dc.contributor.author | Harding, Martha J. | - |
dc.contributor.author | Park, Jong-Hyun | - |
dc.contributor.author | Tobiasova, Zuzana | - |
dc.contributor.author | Kim, Da-Young | - |
dc.contributor.author | Maher, Stephen E. | - |
dc.contributor.author | Chae, Wook-Jin | - |
dc.contributor.author | Park, Sung-Ho | - |
dc.contributor.author | Lee, Chun-Geun | - |
dc.contributor.author | Lee, Sang-Kyou | - |
dc.contributor.author | Bothwell, Alfred L. M. | - |
dc.date.accessioned | 2022-12-20T11:39:59Z | - |
dc.date.available | 2022-12-20T11:39:59Z | - |
dc.date.created | 2022-08-26 | - |
dc.date.issued | 2010-10 | - |
dc.identifier.issn | 0027-8424 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/hanyang/handle/2021.sw.hanyang/173674 | - |
dc.description.abstract | Foxp3 is a key transcription factor for differentiation and function of regulatory T (Treg) cells that is critical for maintaining immunological self-tolerance. Therefore, increasing Treg function by Foxp3 transduction to regulate an inflammatory immune response is an important goal for the treatment of autoimmune and allergic diseases. Here we have generated a cell-permeable Foxp3 protein by fusion with the unique human HHph-1-PTD (protein transduction domain), examined its regulatory function in T cells, and characterized its therapeutic effect in autoimmune and allergic disease models. HHph-1-Foxp3 was rapidly and effectively transduced into cells within 30 min and conferred suppressor function to CD4(+)CD25(-)T cells as well as directly inhibiting T-cell activation and proliferation. Systemic delivery of HHph-1 Foxp3 remarkably inhibited the autoimmune symptoms of scurfy mice and the development of colitis induced by scurfy or wild-type CD4 T cells. Moreover, intranasal delivery of HHph-1-Foxp3 strongly suppressed ovalbumin-induced allergic airway inflammation. These results demonstrate the clinical potential of the cell-permeable recombinant HHph-1-Foxp3 protein in autoimmune and hypersensitive allergic diseases. | - |
dc.language | 영어 | - |
dc.language.iso | en | - |
dc.publisher | NATL ACAD SCIENCES | - |
dc.title | Cell-permeable Foxp3 protein alleviates autoimmune disease associated with inflammatory bowel disease and allergic airway inflammation | - |
dc.type | Article | - |
dc.contributor.affiliatedAuthor | Choi, Je-Min | - |
dc.identifier.doi | 10.1073/pnas.1000400107 | - |
dc.identifier.scopusid | 2-s2.0-78649847380 | - |
dc.identifier.wosid | 000283677400064 | - |
dc.identifier.bibliographicCitation | PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, v.107, no.43, pp.18575 - 18580 | - |
dc.relation.isPartOf | PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA | - |
dc.citation.title | PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA | - |
dc.citation.volume | 107 | - |
dc.citation.number | 43 | - |
dc.citation.startPage | 18575 | - |
dc.citation.endPage | 18580 | - |
dc.type.rims | ART | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
dc.description.isOpenAccess | Y | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Science & Technology - Other Topics | - |
dc.relation.journalWebOfScienceCategory | Multidisciplinary Sciences | - |
dc.subject.keywordPlus | REGULATORY T-CELLS | - |
dc.subject.keywordPlus | IN-VIVO | - |
dc.subject.keywordPlus | SCURFY MOUSE | - |
dc.subject.keywordPlus | DELIVERY | - |
dc.subject.keywordPlus | MICE | - |
dc.subject.keywordPlus | EXPRESSION | - |
dc.subject.keywordPlus | TOLERANCE | - |
dc.subject.keywordPlus | LYMPHOCYTES | - |
dc.subject.keywordPlus | ENTEROPATHY | - |
dc.subject.keywordPlus | ACTIVATION | - |
dc.subject.keywordAuthor | protein transduction domain | - |
dc.subject.keywordAuthor | immunotherapy | - |
dc.subject.keywordAuthor | autoimmunity | - |
dc.subject.keywordAuthor | allergy | - |
dc.identifier.url | https://www.pnas.org/doi/full/10.1073/pnas.1000400107 | - |
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