Diagnostic value of cystatin C for predicting acute kidney injury in patients with liver cirrhosis
DC Field | Value | Language |
---|---|---|
dc.contributor.author | 정미연 | - |
dc.contributor.author | 전대원 | - |
dc.contributor.author | 성수아 | - |
dc.date.accessioned | 2022-12-20T11:44:39Z | - |
dc.date.available | 2022-12-20T11:44:39Z | - |
dc.date.created | 2022-09-19 | - |
dc.date.issued | 2010-09 | - |
dc.identifier.issn | 2287-2728 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/hanyang/handle/2021.sw.hanyang/173701 | - |
dc.description.abstract | Background/Aims: The present study aimed to determine the role of cystatin C as a prognostic factor for acute kidney injury and survival in cirrhotic patients. Methods: The study investigated 53 liver cirrhosis patients. The renal function was evaluated by serum creatinine, serum and urine cystatin C, and 24-hour creatinine clearance on admission. Acute kidney injury was defined as a serum creatinine level exceeding the normal range (>1.2 mg/dl) and an increase of at least 50% from the baseline value. Multivariate analysis, receiver operating characteristic curve, and survival analysis were used to investigate prognostic factors for acute kidney injury and survival. Results: Nine of the 53 cirrhotic patients (17.0%) developed acute kidney injury within 3 months. Both serum creatinine and cystatin C were predictive factors for acute kidney injury in univariate analysis, with a diagnostic accuracy of 0.735 (95% confidence interval (CI), 0.525-0.945; p=0.028) for serum cystatin C and 0.698 (95% CI, 0.495-0.901, p=0.063) for creatinine. In multivariate analysis, only serum cystatin C was an independent risk factor for acute kidney injury. The sensitivity and specificity of a serum cystatin C level of >1.23 mg/L to acute kidney injury were 66% and 86%, respectively. Serum cystatin C was positively correlated with the Model for End-Stage Liver Disease (MELD) and MELD-Na scores (r=0.346 and p=0.011, and r=0.427 and p=0.001, respectively). Comparison of the survival rates over the observation period revealed that a serum cystatin C level of >1.23 mg/L was a useful marker for short-term mortality (p<0.001). Conclusions: The accuracy in predicting acute kidney injury and short-term mortality was higher for a serum cystatin C level of >1.23 mg/L than for the serum creatinine concentration in patients with cirrhosis. | - |
dc.language | 영어 | - |
dc.language.iso | en | - |
dc.publisher | 대한간학회 | - |
dc.title | Diagnostic value of cystatin C for predicting acute kidney injury in patients with liver cirrhosis | - |
dc.title.alternative | Diagnostic value of cystatin C for predicting acute kidney injury in patients with liver cirrhosis | - |
dc.type | Article | - |
dc.contributor.affiliatedAuthor | 전대원 | - |
dc.identifier.doi | 10.3350/kjhep.2010.16.3.301 | - |
dc.identifier.bibliographicCitation | Clinical and Molecular Hepatology, v.16, no.3, pp.301 - 307 | - |
dc.relation.isPartOf | Clinical and Molecular Hepatology | - |
dc.citation.title | Clinical and Molecular Hepatology | - |
dc.citation.volume | 16 | - |
dc.citation.number | 3 | - |
dc.citation.startPage | 301 | - |
dc.citation.endPage | 307 | - |
dc.type.rims | ART | - |
dc.identifier.kciid | ART001481072 | - |
dc.description.journalClass | 2 | - |
dc.description.isOpenAccess | N | - |
dc.description.journalRegisteredClass | kci | - |
dc.subject.keywordAuthor | Cystatin C | - |
dc.subject.keywordAuthor | Liver cirrhosis | - |
dc.subject.keywordAuthor | Acute kidney injury | - |
dc.subject.keywordAuthor | Cystatin C | - |
dc.subject.keywordAuthor | Liver cirrhosis | - |
dc.subject.keywordAuthor | Acute kidney injury | - |
dc.identifier.url | https://www.e-cmh.org/journal/view.php?doi=10.3350/kjhep.2010.16.3.301 | - |
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