Efficacy and safety of tadalafil 5 mg administered once daily in Korean men with erectile dysfunction: A prospective, multicenter studyopen access
- Authors
- Kang, Dong Hyuk; Lee, Joo Yong; Park, Sung Yul; Moon, Hong Sang; Jeong, Tae Yoong; Yoo, Tag Keun; Choi, Hong Yong; Park, Hae Young; Lee, Tchun Yong; Lee, Seung Wook
- Issue Date
- Sep-2010
- Publisher
- 대한비뇨의학회
- Keywords
- Erectile dysfunction; Safety; Tadalafil; Treatment outcome
- Citation
- Korean Journal of Urology, v.51, no.9, pp.647 - 652
- Indexed
- SCOPUS
KCI
- Journal Title
- Korean Journal of Urology
- Volume
- 51
- Number
- 9
- Start Page
- 647
- End Page
- 652
- URI
- https://scholarworks.bwise.kr/hanyang/handle/2021.sw.hanyang/174138
- DOI
- 10.4111/kju.2010.51.9.647
- ISSN
- 2005-6737
- Abstract
- Purpose: The aim of this study was to evaluate the efficacy of a daily dose of tadalafil 5 mg as well as its safety for the cardiovascular system in men with erectile dysfunction. Materials and Methods: This study included a total of 162 men who were administered a daily dose of tadalafil 5 mg between April and December of 2009. A total of 127 men completed the 8-week clinical trial. The International Index of Erectile Function (IIEF)-5, blood pressure, and heart rate were measured before treatment with tadalafil (V1) and 4 (V2) and 8 weeks (V3) after treatment with tadalafil. Adverse effects were assessed at V1, V2, and V3. In cases in which the International Prostate Symptom Score (IPSS) was ≥ 8 at V1, maximal flow rate (Qmax) and postvoid residual volume (PVR) were measured. Results: The IIEF-5 values were 11.25±3.18, 14.56±3.79, and 16.91±3.56 at V1, V2, and V3, respectively, with significant improvement (V1 vs. V2, p<0.001; V1 vs. V3, p <0.001). The IPSS values were 10.59±5.56, 9.07±6.06, and 8.15±6.10 at V1, V2, and V3, respectively, and the differences were statistically significant (V1 vs. V2, p<0.001; V1 vs. V3, p<0.001). There were no significant differences in blood pressure or heart rate. Adverse effects were observed in 7 men (5.51%) at V2 and in 5 men (3.94%) at V3. Conclusions: Tadalafil 5 mg administered once-a-day may be effective in improving erectile function. Adverse effects on the cardiovascular system may be minimal. In addition, it is believed that this may also be effective in improving voiding symptoms.
- Files in This Item
-
- Appears in
Collections - 서울 의과대학 > 서울 비뇨의학교실 > 1. Journal Articles
![qrcode](https://api.qrserver.com/v1/create-qr-code/?size=55x55&data=https://scholarworks.bwise.kr/hanyang/handle/2021.sw.hanyang/174138)
Items in ScholarWorks are protected by copyright, with all rights reserved, unless otherwise indicated.